CD4 [The Human Chemical-Genetic Interaction Map Project]

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======= CD4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD4
  * **<color #00a2e8>Official Name</color>**: CD4 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=920|920]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01730|P01730]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186940|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T- helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. {ECO:0000269|PubMed:16951326, ECO:0000269|PubMed:24942581, ECO:0000269|PubMed:2823150}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|CD4-extracel|
|V-set|
|Tcell CD4 Cterm|
|C2-set|
|ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-16 receptor activity|
|helper T cell enhancement of adaptive immune response|
|induction by virus of host cell-cell fusion|
|interleukin-16 binding|
|immunoglobulin binding|
|MHC class II protein binding|
|fusion of virus membrane with host plasma membrane|
|membrane fusion involved in viral entry into host cell|
|multi-organism membrane fusion|
|cellular response to granulocyte macrophage colony-stimulating factor stimulus|
|positive regulation of viral entry into host cell|
|response to granulocyte macrophage colony-stimulating factor|
|positive regulation of monocyte differentiation|
|multi-organism membrane organization|
|interleukin-15-mediated signaling pathway|
|positive regulation of interleukin-2 biosynthetic process|
|cellular response to interleukin-15|
|response to interleukin-15|
|regulation of monocyte differentiation|
|modulation by virus of host cellular process|
|regulation of interleukin-2 biosynthetic process|
|multi-organism cellular process|
|macrophage differentiation|
|protein tyrosine kinase binding|
|modulation by symbiont of host cellular process|
|regulation of defense response to virus by virus|
|positive regulation of interleukin-2 production|
|response to vitamin D|
|regulation of viral entry into host cell|
|modulation by virus of host morphology or physiology|
|coreceptor activity|
|T cell selection|
|modification by symbiont of host morphology or physiology|
|positive regulation of calcium-mediated signaling|
|clathrin-coated vesicle membrane|
|regulation of interleukin-2 production|
|positive regulation of calcium ion transport into cytosol|
|positive regulation of myeloid leukocyte differentiation|
|positive regulation of viral life cycle|
|positive regulation of cytokine biosynthetic process|
|maintenance of protein location in cell|
|virus receptor activity|
|defense response to Gram-negative bacterium|
|response to vitamin|
|positive regulation of myeloid cell differentiation|
|positive regulation of T cell proliferation|
|viral entry into host cell|
|maintenance of location in cell|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|entry into host cell|
|entry into host|
|regulation of cytokine biosynthetic process|
|positive regulation of adaptive immune response|
|maintenance of protein location|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|myeloid leukocyte differentiation|
|regulation of myeloid leukocyte differentiation|
|positive regulation of calcium ion transport|
|T cell receptor complex|
|positive regulation of lymphocyte proliferation|
|membrane fusion|
|positive regulation of mononuclear cell proliferation|
|extracellular matrix structural constituent|
|T cell differentiation|
|response to estradiol|
|positive regulation of leukocyte proliferation|
|transmembrane signaling receptor activity|
|regulation of viral life cycle|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|cytokine production|
|modification of morphology or physiology of other organism|
|interaction with host|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|maintenance of location|
|T cell receptor signaling pathway|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|viral life cycle|
|positive regulation of T cell activation|
|signaling receptor activity|
|regulation of viral process|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of ERK1 and ERK2 cascade|
|response to nutrient|
|positive regulation of leukocyte cell-cell adhesion|
|myeloid cell differentiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of leukocyte proliferation|
|regulation of myeloid cell differentiation|
|membrane raft|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|T cell activation|
|lymphocyte differentiation|
|regulation of calcium ion transport|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|early endosome|
|regulation of leukocyte differentiation|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|regulation of ERK1 and ERK2 cascade|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|endoplasmic reticulum lumen|
|regulation of T cell activation|
|regulation of cytosolic calcium ion concentration|
|defense response to bacterium|
|leukocyte differentiation|
|enzyme binding|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|regulation of metal ion transport|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|cellular calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|regulation of hemopoiesis|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|immune response-regulating cell surface receptor signaling pathway|
|divalent inorganic cation homeostasis|
|response to nutrient levels|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|cellular metal ion homeostasis|
|hemopoiesis|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|immune system development|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of ion transport|
|viral process|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|regulation of multi-organism process|
|symbiotic process|
|ion homeostasis|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|zinc ion binding|
|response to lipid|
|membrane organization|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|cellular homeostasis|
|response to hormone|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|endoplasmic reticulum membrane|
|defense response to other organism|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|response to cytokine|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.72|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4155
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD4 Expression in NALM6 Cells: -0.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>