CD59 [The Human Chemical-Genetic Interaction Map Project]

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======= CD59 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD59
  * **<color #00a2e8>Official Name</color>**: CD59 molecule (CD59 blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=966|966]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13987|P13987]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD59&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD59|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107271|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UPAR LY6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of activation of membrane attack complex|
|regulation of activation of membrane attack complex|
|complement binding|
|negative regulation of complement activation|
|regulation of complement-dependent cytotoxicity|
|negative regulation of humoral immune response|
|anchored component of external side of plasma membrane|
|ER to Golgi transport vesicle membrane|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|tertiary granule membrane|
|Golgi vesicle budding|
|vesicle targeting|
|specific granule membrane|
|transport vesicle|
|vesicle budding from membrane|
|regulation of cell killing|
|regulation of complement activation|
|negative regulation of immune effector process|
|regulation of humoral immune response|
|vesicle|
|negative regulation of immune response|
|establishment of vesicle localization|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|blood coagulation|
|coagulation|
|hemostasis|
|vesicle organization|
|establishment of organelle localization|
|Golgi vesicle transport|
|focal adhesion|
|negative regulation of immune system process|
|regulation of immune effector process|
|wound healing|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|response to wounding|
|organelle localization|
|myeloid leukocyte activation|
|cell surface|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|membrane organization|
|leukocyte activation|
|endoplasmic reticulum membrane|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|regulation of immune response|
|intracellular transport|
|protein-containing complex assembly|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.02|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18651
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD59 Expression in NALM6 Cells: 3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>