CD79A [The Human Chemical-Genetic Interaction Map Project]

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======= CD79A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD79A
  * **<color #00a2e8>Official Name</color>**: CD79a molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=973|973]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11912|P11912]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD79A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD79A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/112205|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells. {ECO:0000269|PubMed:8617796, ECO:0000269|PubMed:9057631}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|V-set|
|ITAM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|B cell receptor complex|
|multivesicular body|
|B cell proliferation|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|protein homotetramerization|
|leukocyte proliferation|
|B cell differentiation|
|B cell receptor signaling pathway|
|transmembrane signaling receptor activity|
|protein tetramerization|
|B cell activation|
|membrane raft|
|lymphocyte differentiation|
|antigen receptor-mediated signaling pathway|
|leukocyte differentiation|
|protein homooligomerization|
|lymphocyte activation|
|external side of plasma membrane|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|protein complex oligomerization|
|cell population proliferation|
|hemopoiesis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|activation of immune response|
|immune system development|
|positive regulation of immune response|
|protein homodimerization activity|
|leukocyte activation|
|cell activation|
|regulation of immune response|
|positive regulation of immune system process|
|protein-containing complex assembly|
|regulation of immune system process|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.12|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.93|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.72|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.72|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.71|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.71|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.71|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.74|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.75|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.8|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.81|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.84|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.95|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.03|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.05|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.07|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.15|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.18|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.33|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.48|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.54|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.91|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.95|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.97|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.99|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|3.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:igll1|IGLL1]]|0.714|
|[[:human genes:s:syk|SYK]]|0.707|
|[[:human genes:c:cd79b|CD79B]]|0.686|
|[[:human genes:e:ergic1|ERGIC1]]|0.644|
|[[:human genes:r:rhoh|RHOH]]|0.629|
|[[:human genes:c:cd19|CD19]]|0.577|
|[[:human genes:p:pik3cd|PIK3CD]]|0.533|
|[[:human genes:c:cd81|CD81]]|0.496|
|[[:human genes:r:rrm1|RRM1]]|0.49|
|[[:human genes:v:vezf1|VEZF1]]|0.453|
|[[:human genes:g:ganab|GANAB]]|0.442|
|[[:human genes:s:ssr3|SSR3]]|0.433|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.416|
|[[:human genes:r:rictor|RICTOR]]|0.409|
|[[:human genes:a:akt2|AKT2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1242
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD79A Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>