CDAN1 [The Human Chemical-Genetic Interaction Map Project]

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======= CDAN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDAN1
  * **<color #00a2e8>Official Name</color>**: codanin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=146059|146059]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWY9|Q8IWY9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDAN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDAN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607465|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a negative regulator of ASF1 in chromatin assembly. {ECO:0000269|PubMed:22407294}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of DNA replication|
|endomembrane system|
|regulation of DNA replication|
|chromatin assembly|
|chromatin assembly or disassembly|
|DNA packaging|
|DNA conformation change|
|chromatin organization|
|chromosome organization|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.36|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.28|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.93|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.9|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.8|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.75|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.75|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.81|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.82|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.96|
|[[:results:exp303|39°C R06 exp303]]|1.97|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.97|
|[[:results:exp461|BS-181 20μM R08 exp461]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 471/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|12/28|
|blood|25/28|
|bone|20/25|
|breast|22/33|
|central nervous system|42/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|7/15|
|kidney|12/21|
|liver|12/20|
|lung|49/75|
|lymphocyte|11/14|
|ovary|12/26|
|pancreas|8/24|
|peripheral nervous system|12/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|4/7|
|thyroid|1/2|
|upper aerodigestive|11/22|
|urinary tract|20/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2049
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDAN1 Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>