CDH13 [The Human Chemical-Genetic Interaction Map Project]

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======= CDH13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDH13
  * **<color #00a2e8>Official Name</color>**: cadherin 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1012|1012]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55290|P55290]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDH13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDH13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601364|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. {ECO:0000269|PubMed:10737605}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin pro|
|Cadherin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adiponectin binding|
|low-density lipoprotein particle mediated signaling|
|lipoprotein particle mediated signaling|
|lipoprotein particle binding|
|keratinocyte proliferation|
|low-density lipoprotein particle binding|
|cellular response to low-density lipoprotein particle stimulus|
|Rac protein signal transduction|
|positive regulation of positive chemotaxis|
|regulation of positive chemotaxis|
|cell-cell adhesion mediated by cadherin|
|response to lipoprotein particle|
|cellular response to lipoprotein particle stimulus|
|catenin complex|
|lamellipodium assembly|
|lamellipodium organization|
|positive regulation of calcium-mediated signaling|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|positive regulation of cell-matrix adhesion|
|sprouting angiogenesis|
|endothelial cell migration|
|GABA-ergic synapse|
|caveola|
|cytoskeletal protein binding|
|Rho protein signal transduction|
|epithelial cell migration|
|regulation of epidermal growth factor receptor signaling pathway|
|adherens junction organization|
|localization within membrane|
|positive regulation of smooth muscle cell proliferation|
|epithelium migration|
|epithelial cell proliferation|
|regulation of ERBB signaling pathway|
|positive regulation of endothelial cell proliferation|
|tissue migration|
|regulation of calcium-mediated signaling|
|anchored component of membrane|
|cell-cell adherens junction|
|cell-cell junction assembly|
|regulation of cell-matrix adhesion|
|positive regulation of cell-substrate adhesion|
|regulation of endothelial cell proliferation|
|regulation of smooth muscle cell proliferation|
|positive regulation of chemotaxis|
|cell-cell junction organization|
|cell junction assembly|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|ameboidal-type cell migration|
|positive regulation of epithelial cell proliferation|
|regulation of endocytosis|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|cell junction organization|
|Ras protein signal transduction|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|negative regulation of cell adhesion|
|cadherin binding|
|angiogenesis|
|small GTPase mediated signal transduction|
|neuron projection|
|regulation of epithelial cell proliferation|
|collagen-containing extracellular matrix|
|external side of plasma membrane|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|focal adhesion|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|blood vessel development|
|positive regulation of cell migration|
|cell-cell adhesion|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell population proliferation|
|positive regulation of response to external stimulus|
|cell surface|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|calcium ion binding|
|cell morphogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of transcription by RNA polymerase II|
|locomotion|
|cell cycle|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|extracellular space|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.43|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17499
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDH13 Expression in NALM6 Cells: 2.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>