CDH22 [The Human Chemical-Genetic Interaction Map Project]

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======= CDH22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDH22
  * **<color #00a2e8>Official Name</color>**: cadherin 22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64405|64405]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJ99|Q9UJ99]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDH22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDH22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609920|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin|
|Cadherin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell-cell adhesion mediated by cadherin|
|catenin complex|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|cytoskeletal protein binding|
|adherens junction organization|
|cell-cell adherens junction|
|cell-cell junction assembly|
|cell-cell junction organization|
|cell junction assembly|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|cell junction organization|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|cadherin binding|
|cell-cell adhesion|
|cell surface|
|calcium ion binding|
|cell morphogenesis|
|brain development|
|head development|
|cellular component morphogenesis|
|protein homodimerization activity|
|cell adhesion|
|biological adhesion|
|central nervous system development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.97|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.81|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.8|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.77|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.82|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.99|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.17|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.41|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8629
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDH22 Expression in NALM6 Cells: 0.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>