CDH24 [The Human Chemical-Genetic Interaction Map Project]

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======= CDH24 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDH24
  * **<color #00a2e8>Official Name</color>**: cadherin 24
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64403|64403]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86UP0|Q86UP0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDH24&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDH24|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618599|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion. {ECO:0000269|PubMed:12734196}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin C|
|Cadherin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell-cell adhesion mediated by cadherin|
|catenin complex|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|cytoskeletal protein binding|
|adherens junction organization|
|cell-cell adherens junction|
|cell-cell junction assembly|
|cell-cell junction organization|
|cell junction assembly|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|cell-cell junction|
|cell junction organization|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|cadherin binding|
|cell-cell adhesion|
|cell surface|
|calcium ion binding|
|cell morphogenesis|
|cellular component morphogenesis|
|protein homodimerization activity|
|cell adhesion|
|biological adhesion|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.91|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.73|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.75|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.76|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|1.82|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.522|
|[[:human genes:a:aamp|AAMP]]|0.51|
|[[:human genes:p:polr2j3|POLR2J3]]|0.509|
|[[:human genes:s:slc4a1|SLC4A1]]|0.505|
|[[:human genes:c:chd4|CHD4]]|0.505|
|[[:human genes:e:exosc9|EXOSC9]]|0.491|
|[[:human genes:n:napa|NAPA]]|0.48|
|[[:human genes:t:tceb3c|TCEB3C]]|0.479|
|[[:human genes:v:vps28|VPS28]]|0.476|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.464|
|[[:human genes:p:psmb4|PSMB4]]|0.463|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.462|
|[[:human genes:d:dock6|DOCK6]]|0.457|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.452|
|[[:human genes:c:col2a1|COL2A1]]|0.45|
|[[:human genes:n:npipb5|NPIPB5]]|0.45|
|[[:human genes:c:cln6|CLN6]]|0.449|
|[[:human genes:r:rpl35|RPL35]]|0.448|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.448|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.446|
|[[:human genes:z:znf541|ZNF541]]|0.446|
|[[:human genes:c:chaf1a|CHAF1A]]|0.443|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.441|
|[[:human genes:d:ddx47|DDX47]]|0.439|
|[[:human genes:o:osbp|OSBP]]|0.438|
|[[:human genes:r:rpl6|RPL6]]|0.435|
|[[:human genes:r:rad51|RAD51]]|0.434|
|[[:human genes:e:exosc5|EXOSC5]]|0.434|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.433|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.433|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.433|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.433|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.433|
|[[:human genes:p:pold1|POLD1]]|0.433|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.431|
|[[:human genes:t:ticrr|TICRR]]|0.428|
|[[:human genes:i:ik|IK]]|0.428|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.427|
|[[:human genes:p:psmb2|PSMB2]]|0.427|
|[[:human genes:a:akt1s1|AKT1S1]]|0.427|
|[[:human genes:p:pno1|PNO1]]|0.427|
|[[:human genes:l:loc643669|LOC643669]]|0.427|
|[[:human genes:t:tyms|TYMS]]|0.425|
|[[:human genes:n:nup153|NUP153]]|0.425|
|[[:human genes:p:polr2d|POLR2D]]|0.423|
|[[:human genes:u:utp3|UTP3]]|0.423|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.422|
|[[:human genes:o:orc6|ORC6]]|0.42|
|[[:human genes:x:xab2|XAB2]]|0.42|
|[[:human genes:d:dtl|DTL]]|0.42|
|[[:human genes:a:aqr|AQR]]|0.42|
|[[:human genes:s:sf3a2|SF3A2]]|0.419|
|[[:human genes:c:celf6|CELF6]]|0.418|
|[[:human genes:c:cope|COPE]]|0.418|
|[[:human genes:s:snrpa1|SNRPA1]]|0.417|
|[[:human genes:g:gramd1a|GRAMD1A]]|0.417|
|[[:human genes:s:supt5h|SUPT5H]]|0.417|
|[[:human genes:n:nol10|NOL10]]|0.417|
|[[:human genes:c:copg1|COPG1]]|0.417|
|[[:human genes:m:mfsd12|MFSD12]]|0.417|
|[[:human genes:m:myo18a|MYO18A]]|0.416|
|[[:human genes:s:syt9|SYT9]]|0.416|
|[[:human genes:n:narfl|NARFL]]|0.415|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.414|
|[[:human genes:c:cactin|CACTIN]]|0.413|
|[[:human genes:p:plekha4|PLEKHA4]]|0.412|
|[[:human genes:a:abhd8|ABHD8]]|0.411|
|[[:human genes:c:cacna1a|CACNA1A]]|0.411|
|[[:human genes:d:disp2|DISP2]]|0.41|
|[[:human genes:m:mbtd1|MBTD1]]|0.41|
|[[:human genes:s:snrnp70|SNRNP70]]|0.409|
|[[:human genes:k:krt78|KRT78]]|0.409|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.408|
|[[:human genes:n:nsf|NSF]]|0.408|
|[[:human genes:s:slc7a6os|SLC7A6OS]]|0.408|
|[[:human genes:t:tsg101|TSG101]]|0.408|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.407|
|[[:human genes:p:pole|POLE]]|0.406|
|[[:human genes:s:ssh2|SSH2]]|0.405|
|[[:human genes:k:kif3c|KIF3C]]|0.405|
|[[:human genes:c:cdca3|CDCA3]]|0.402|
|[[:human genes:e:eif4a3|EIF4A3]]|0.402|
|[[:human genes:m:mki67ip|MKI67IP]]|0.402|
|[[:human genes:p:psmd3|PSMD3]]|0.402|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.401|
|[[:human genes:m:mms22l|MMS22L]]|0.401|
|[[:human genes:a:ankle1|ANKLE1]]|0.4|
|[[:human genes:p:psma6|PSMA6]]|0.4|
|[[:human genes:p:psmd2|PSMD2]]|0.4|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.4|
|[[:human genes:c:copb1|COPB1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2023
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDH24 Expression in NALM6 Cells: 4.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>