CDH8 [The Human Chemical-Genetic Interaction Map Project]

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======= CDH8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDH8
  * **<color #00a2e8>Official Name</color>**: cadherin 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1006|1006]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55286|P55286]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDH8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDH8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603008|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin C|
|Cadherin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|synaptic cleft|
|synaptic membrane|
|cell-cell adhesion mediated by cadherin|
|synaptic transmission, glutamatergic|
|catenin complex|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|response to cold|
|axon terminus|
|cytoskeletal protein binding|
|adherens junction organization|
|cell-cell junction assembly|
|cell-cell adherens junction|
|cell-cell junction organization|
|cell junction assembly|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|response to temperature stimulus|
|cell junction organization|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|cadherin binding|
|glutamatergic synapse|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|synaptic signaling|
|cell-cell adhesion|
|cell surface|
|calcium ion binding|
|cell morphogenesis|
|cellular component morphogenesis|
|protein homodimerization activity|
|cell adhesion|
|biological adhesion|
|cell-cell signaling|
|response to abiotic stimulus|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.07|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.86|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.82|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9968
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDH8 Expression in NALM6 Cells: 1.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>