CDK2AP2 [The Human Chemical-Genetic Interaction Map Project]

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======= CDK2AP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDK2AP2
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase 2 associated protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10263|10263]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75956|O75956]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDK2AP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDK2AP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620061|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148). {ECO:0000250|UniProtKB:Q9CPY4, ECO:0000269|PubMed:23781148}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDK2AP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of stem cell division|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of cell cycle G1/S phase transition|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|regulation of cell division|
|regulation of microtubule cytoskeleton organization|
|negative regulation of mitotic cell cycle phase transition|
|regulation of microtubule-based process|
|negative regulation of cell cycle phase transition|
|negative regulation of mitotic cell cycle|
|microtubule|
|negative regulation of cell cycle process|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|regulation of cytoskeleton organization|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|regulation of cell cycle process|
|regulation of cell cycle|
|regulation of organelle organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3900
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDK2AP2 Expression in NALM6 Cells: 4.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>