CDK5 [The Human Chemical-Genetic Interaction Map Project]

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======= CDK5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDK5
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1020|1020]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q00535|Q00535]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDK5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDK5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123831|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma- dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin- dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1- EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:12393264, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15992363, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17121855, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17611284, ECO:0000269|PubMed:17671990, ECO:0000269|PubMed:18042622, ECO:0000269|PubMed:19081376, ECO:0000269|PubMed:19693690, ECO:0000269|PubMed:20061803, ECO:0000269|PubMed:20213743, ECO:0000269|PubMed:20826806, ECO:0000269|PubMed:21209322, ECO:0000269|PubMed:21220307, ECO:0000269|PubMed:21442427, ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:21499257, ECO:0000269|PubMed:24235147, ECO:0000269|PubMed:9822744}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of glial cell apoptotic process|
|protein kinase 5 complex|
|induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration|
|ErbB-3 class receptor binding|
|positive regulation of presynaptic cytosolic calcium concentration|
|serine phosphorylation of STAT protein|
|acetylcholine receptor activator activity|
|ErbB-2 class receptor binding|
|voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels|
|negative regulation of synaptic plasticity|
|negative regulation of protein export from nucleus|
|positive regulation of synaptic vesicle exocytosis|
|regulation of glial cell apoptotic process|
|synapse pruning|
|layer formation in cerebral cortex|
|presynaptic modulation of chemical synaptic transmission|
|corpus callosum development|
|regulation of presynaptic cytosolic calcium ion concentration|
|positive regulation of actin cytoskeleton reorganization|
|synaptic transmission, dopaminergic|
|positive regulation of calcium ion-dependent exocytosis|
|negative regulation of nucleocytoplasmic transport|
|behavioral response to cocaine|
|cerebellar cortex formation|
|positive regulation of neurotransmitter secretion|
|telencephalon glial cell migration|
|maintenance of protein location in nucleus|
|cerebral cortex radial glia guided migration|
|tau-protein kinase activity|
|regulation of synaptic vesicle recycling|
|receptor catabolic process|
|ephrin receptor binding|
|motor neuron axon guidance|
|cerebral cortex radially oriented cell migration|
|synaptic transmission, glutamatergic|
|cyclin-dependent protein serine/threonine kinase activity|
|Schwann cell development|
|histone phosphorylation|
|cerebellar cortex morphogenesis|
|positive regulation of protein targeting to membrane|
|neuron cellular homeostasis|
|axon extension|
|Schwann cell differentiation|
|synaptic vesicle transport|
|glial cell migration|
|regulation of actin cytoskeleton reorganization|
|regulation of protein targeting to membrane|
|cerebellum morphogenesis|
|regulation of protein export from nucleus|
|positive regulation of neurotransmitter transport|
|cellular response to amyloid-beta|
|maintenance of protein localization in organelle|
|synaptic vesicle localization|
|hindbrain morphogenesis|
|Hsp90 protein binding|
|negative regulation of intracellular protein transport|
|cortical actin cytoskeleton organization|
|negative regulation of axon extension|
|regulation of dendritic spine morphogenesis|
|cerebral cortex cell migration|
|calcium ion import|
|regulation of calcium ion-dependent exocytosis|
|neuron apoptotic process|
|presynaptic endocytosis|
|synaptic vesicle endocytosis|
|tau protein binding|
|receptor clustering|
|cerebellar cortex development|
|cortical cytoskeleton organization|
|visual learning|
|response to amyloid-beta|
|neuron death|
|synaptic vesicle recycling|
|visual behavior|
|positive regulation of regulated secretory pathway|
|positive regulation of neuron apoptotic process|
|response to cocaine|
|telencephalon cell migration|
|dendrite morphogenesis|
|negative regulation of intracellular transport|
|neuron projection extension|
|forebrain cell migration|
|protein localization to synapse|
|excitatory postsynaptic potential|
|synaptic vesicle exocytosis|
|p53 binding|
|chemical synaptic transmission, postsynaptic|
|regulation of synaptic transmission, glutamatergic|
|oligodendrocyte differentiation|
|negative regulation of axonogenesis|
|filopodium|
|regulation of dendritic spine development|
|peripheral nervous system development|
|negative regulation of protein ubiquitination|
|maintenance of protein location in cell|
|sensory perception of pain|
|regulation of neurotransmitter receptor activity|
|neuromuscular junction|
|associative learning|
|response to anesthetic|
|regulation of synaptic vesicle exocytosis|
|central nervous system neuron development|
|kinase activity|
|hippocampus development|
|regulation of protein targeting|
|peptidyl-threonine phosphorylation|
|Schaffer collateral - CA1 synapse|
|negative regulation of protein modification by small protein conjugation or removal|
|localization within membrane|
|developmental cell growth|
|positive regulation of exocytosis|
|cell growth|
|regulation of dendrite morphogenesis|
|peptidyl-threonine modification|
|positive regulation of neuron death|
|positive regulation of protein binding|
|synapse assembly|
|regulation of protein localization to plasma membrane|
|presynapse|
|maintenance of location in cell|
|regulation of postsynapse organization|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of postsynaptic membrane potential|
|neurotransmitter secretion|
|signal release from synapse|
|dendrite development|
|cerebellum development|
|receptor metabolic process|
|negative regulation of developmental growth|
|regulation of neurotransmitter secretion|
|regulation of nucleocytoplasmic transport|
|maintenance of protein location|
|regulation of cell cycle arrest|
|glial cell development|
|limbic system development|
|regulation of extent of cell growth|
|metencephalon development|
|negative regulation of cellular protein localization|
|regulation of synaptic vesicle cycle|
|response to alkaloid|
|regulation of protein localization to cell periphery|
|developmental growth involved in morphogenesis|
|cerebral cortex development|
|synaptic vesicle cycle|
|neuron migration|
|positive regulation of protein localization to membrane|
|skeletal muscle tissue development|
|cell-matrix adhesion|
|growth cone|
|regulation of receptor signaling pathway via JAK-STAT|
|vesicle-mediated transport in synapse|
|skeletal muscle organ development|
|perikaryon|
|regulation of receptor signaling pathway via STAT|
|regulation of neurotransmitter transport|
|adult behavior|
|learning|
|regulation of dendrite development|
|hindbrain development|
|positive regulation of synaptic transmission|
|positive regulation of intracellular protein transport|
|negative regulation of neuron projection development|
|protein localization to nucleus|
|maintenance of location|
|regulation of regulated secretory pathway|
|signal release|
|glial cell differentiation|
|regulation of macroautophagy|
|regulation of signaling receptor activity|
|pallium development|
|peptidyl-serine phosphorylation|
|establishment of vesicle localization|
|positive regulation of binding|
|neurotransmitter transport|
|lamellipodium|
|central nervous system neuron differentiation|
|regulation of signal transduction by p53 class mediator|
|negative regulation of cell projection organization|
|negative regulation of protein transport|
|regulation of cell size|
|negative regulation of cell growth|
|response to ammonium ion|
|vesicle localization|
|cell-substrate adhesion|
|regulation of axonogenesis|
|negative regulation of establishment of protein localization|
|regulation of protein localization to membrane|
|regulation of synaptic plasticity|
|protein autophosphorylation|
|peptidyl-serine modification|
|regulation of protein ubiquitination|
|postsynaptic membrane|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|positive regulation of intracellular transport|
|gliogenesis|
|regulation of synapse organization|
|regulation of protein binding|
|positive regulation of cytoskeleton organization|
|regulation of exocytosis|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|regulation of protein modification by small protein conjugation or removal|
|regulation of intracellular protein transport|
|protein kinase activity|
|microtubule binding|
|negative regulation of growth|
|calcium ion transport|
|postsynaptic density|
|telencephalon development|
|learning or memory|
|axon guidance|
|neuron projection guidance|
|nucleocytoplasmic transport|
|nuclear transport|
|synapse organization|
|rhythmic process|
|positive regulation of cytosolic calcium ion concentration|
|striated muscle tissue development|
|negative regulation of neurogenesis|
|axon|
|divalent metal ion transport|
|muscle organ development|
|muscle tissue development|
|cognition|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|regulation of cell morphogenesis involved in differentiation|
|response to light stimulus|
|regulation of neuron death|
|negative regulation of nervous system development|
|microtubule|
|neuron projection|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|regulation of developmental growth|
|regulation of autophagy|
|negative regulation of cell development|
|anatomical structure homeostasis|
|regulation of actin cytoskeleton organization|
|glutamatergic synapse|
|regulation of intracellular transport|
|regulation of neurotransmitter levels|
|negative regulation of proteolysis|
|protein serine/threonine kinase activity|
|establishment of organelle localization|
|histone modification|
|axonogenesis|
|neuronal cell body|
|covalent chromatin modification|
|regulation of cellular component size|
|regulation of binding|
|forebrain development|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|cellular component disassembly|
|positive regulation of secretion by cell|
|axon development|
|regulation of cell growth|
|dendrite|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|positive regulation of protein transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|response to radiation|
|mitochondrion organization|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|muscle structure development|
|microtubule cytoskeleton organization|
|protein localization to membrane|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell division|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|cell part morphogenesis|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|cell junction|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|endocytosis|
|cell morphogenesis involved in differentiation|
|cellular metal ion homeostasis|
|actin filament-based process|
|response to wounding|
|behavior|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|organelle localization|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|neuron projection development|
|microtubule-based process|
|regulation of growth|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|chromatin organization|
|regulated exocytosis|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|cell morphogenesis|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of peptide transport|
|brain development|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|head development|
|ion homeostasis|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cation transport|
|regulation of cellular catabolic process|
|regulation of cell migration|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|sensory perception|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of catabolic process|
|intracellular protein transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|secretion by cell|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|export from cell|
|macromolecule catabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|cell death|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|chemical homeostasis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|negative regulation of RNA metabolic process|
|cell cycle|
|ion transport|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|tissue development|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.31|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.75|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.78|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.81|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.83|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fibp|FIBP]]|0.498|
|[[:human genes:k:kiaa0195|KIAA0195]]|0.432|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13761
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDK5 Expression in NALM6 Cells: 4.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>