CDK5R2 [The Human Chemical-Genetic Interaction Map Project]

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======= CDK5R2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDK5R2
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase 5 regulatory subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8941|8941]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13319|Q13319]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDK5R2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDK5R2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603764|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Activator of CDK5/TPKII.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDK5 activator|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|superior olivary nucleus maturation|
|superior olivary nucleus development|
|protein kinase 5 complex|
|pons maturation|
|hindbrain maturation|
|central nervous system maturation|
|cyclin-dependent protein serine/threonine kinase activator activity|
|pons development|
|layer formation in cerebral cortex|
|positive regulation of calcium ion-dependent exocytosis|
|telencephalon glial cell migration|
|cerebral cortex radial glia guided migration|
|cerebral cortex radially oriented cell migration|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|positive regulation of cyclin-dependent protein kinase activity|
|glial cell migration|
|regulation of calcium ion-dependent exocytosis|
|cerebral cortex cell migration|
|positive regulation of regulated secretory pathway|
|telencephalon cell migration|
|forebrain cell migration|
|neural nucleus development|
|hippocampus development|
|positive regulation of exocytosis|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|cerebellum development|
|limbic system development|
|metencephalon development|
|cerebral cortex development|
|neuron migration|
|growth cone|
|anatomical structure maturation|
|hindbrain development|
|lipid binding|
|regulation of regulated secretory pathway|
|pallium development|
|gliogenesis|
|regulation of exocytosis|
|developmental maturation|
|telencephalon development|
|actin binding|
|neuron projection|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of cell cycle|
|forebrain development|
|positive regulation of secretion by cell|
|positive regulation of secretion|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|regulation of vesicle-mediated transport|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|brain development|
|regulation of secretion by cell|
|head development|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|cell migration|
|regulation of transferase activity|
|central nervous system development|
|positive regulation of transport|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|positive regulation of protein modification process|
|locomotion|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4291
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDK5R2 Expression in NALM6 Cells: -2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>