CDK5RAP2 [The Human Chemical-Genetic Interaction Map Project]

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======= CDK5RAP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDK5RAP2
  * **<color #00a2e8>Official Name</color>**: CDK5 regulatory subunit associated protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55755|55755]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96SN8|Q96SN8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDK5RAP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDK5RAP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608201|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Microtub assoc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of centriole replication|
|gamma-tubulin ring complex|
|negative regulation of centrosome duplication|
|negative regulation of centrosome cycle|
|regulation of mitotic cell cycle spindle assembly checkpoint|
|regulation of spindle checkpoint|
|regulation of mitotic spindle checkpoint|
|centriole replication|
|microtubule plus-end|
|pericentriolar material|
|regulation of centriole replication|
|centriole assembly|
|gamma-tubulin binding|
|mitotic spindle pole|
|establishment of mitotic spindle orientation|
|positive regulation of microtubule polymerization|
|centrosome duplication|
|regulation of cell cycle checkpoint|
|establishment of mitotic spindle localization|
|positive regulation of microtubule polymerization or depolymerization|
|establishment of spindle orientation|
|negative regulation of organelle assembly|
|establishment of spindle localization|
|regulation of centrosome duplication|
|spindle localization|
|regulation of mitotic metaphase/anaphase transition|
|regulation of microtubule polymerization|
|regulation of metaphase/anaphase transition of cell cycle|
|tubulin binding|
|regulation of mitotic sister chromatid separation|
|regulation of centrosome cycle|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid segregation|
|regulation of microtubule polymerization or depolymerization|
|centrosome cycle|
|microtubule bundle formation|
|microtubule organizing center organization|
|ciliary basal body-plasma membrane docking|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|establishment of cell polarity|
|spindle pole|
|positive regulation of protein polymerization|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|negative regulation of cytoskeleton organization|
|regulation of mitotic nuclear division|
|organelle localization by membrane tethering|
|membrane docking|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|regulation of G2/M transition of mitotic cell cycle|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|calmodulin binding|
|regulation of cell cycle G2/M phase transition|
|transcription regulatory region DNA binding|
|positive regulation of cytoskeleton organization|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|negative regulation of neuron differentiation|
|microtubule binding|
|positive regulation of protein complex assembly|
|mitotic cell cycle phase transition|
|chromosome segregation|
|cell cycle phase transition|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|microtubule|
|negative regulation of cell cycle process|
|negative regulation of cell development|
|cilium assembly|
|regulation of chromosome organization|
|regulation of supramolecular fiber organization|
|establishment of organelle localization|
|cytoskeleton|
|cilium organization|
|negative regulation of organelle organization|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|cell projection assembly|
|protein kinase binding|
|microtubule cytoskeleton organization|
|centrosome|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|cell junction|
|negative regulation of cell cycle|
|organelle localization|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|microtubule-based process|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|negative regulation of cell differentiation|
|brain development|
|regulation of cell cycle process|
|organelle assembly|
|head development|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|central nervous system development|
|Golgi apparatus|
|cell cycle process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-2.34|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.06|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2906
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDK5RAP2 Expression in NALM6 Cells: 7.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>