CDKL3 [The Human Chemical-Genetic Interaction Map Project]

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======= CDKL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDKL3
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase like 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51265|51265]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IVW4|Q8IVW4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDKL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDKL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608459|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dendrite extension|
|cyclin-dependent protein serine/threonine kinase activity|
|positive regulation of dendrite morphogenesis|
|negative regulation of axon extension|
|neuron projection extension|
|negative regulation of axonogenesis|
|positive regulation of dendrite development|
|developmental cell growth|
|cell growth|
|regulation of dendrite morphogenesis|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of developmental growth|
|regulation of extent of cell growth|
|developmental growth involved in morphogenesis|
|regulation of dendrite development|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|negative regulation of cell projection organization|
|regulation of cell size|
|negative regulation of cell growth|
|regulation of axonogenesis|
|negative regulation of neuron differentiation|
|protein kinase activity|
|negative regulation of growth|
|positive regulation of neuron projection development|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|regulation of developmental growth|
|negative regulation of cell development|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|developmental growth|
|growth|
|regulation of cell growth|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|regulation of anatomical structure size|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|phosphorylation|
|positive regulation of developmental process|
|ATP binding|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.39|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.29|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.16|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.09|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.98|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.86|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.71|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.78|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.89|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.92|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.94|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.1|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.1|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18831
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDKL3 Expression in NALM6 Cells: 1.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>