CDKN2A [The Human Chemical-Genetic Interaction Map Project]

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======= CDKN2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDKN2A
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase inhibitor 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1029|1029]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/"P42771|Q8N726"|"P42771|Q8N726"]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDKN2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDKN2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600160|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|P19Arf N|
|Ank 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|senescence-associated heterochromatin focus assembly|
|senescence-associated heterochromatin focus|
|positive regulation of macrophage apoptotic process|
|positive regulation of myeloid cell apoptotic process|
|heterochromatin assembly|
|regulation of macrophage apoptotic process|
|replicative senescence|
|cyclin-dependent protein serine/threonine kinase inhibitor activity|
|positive regulation of cellular senescence|
|positive regulation of smooth muscle cell apoptotic process|
|positive regulation of cell aging|
|heterochromatin organization|
|regulation of smooth muscle cell apoptotic process|
|positive regulation of muscle cell apoptotic process|
|positive regulation of leukocyte apoptotic process|
|NF-kappaB binding|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of myeloid cell apoptotic process|
|negative regulation of cyclin-dependent protein kinase activity|
|cellular senescence|
|negative regulation of cell-matrix adhesion|
|regulation of cellular senescence|
|regulation of cell aging|
|negative regulation of cell-substrate adhesion|
|cell aging|
|regulation of muscle cell apoptotic process|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of leukocyte apoptotic process|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of G1/S transition of mitotic cell cycle|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell-matrix adhesion|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|negative regulation of protein serine/threonine kinase activity|
|chromatin assembly|
|cell cycle arrest|
|regulation of G1/S transition of mitotic cell cycle|
|chromatin assembly or disassembly|
|negative regulation of DNA-binding transcription factor activity|
|chromatin remodeling|
|regulation of cell cycle G1/S phase transition|
|DNA packaging|
|negative regulation of cell growth|
|regulation of cell-substrate adhesion|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of protein kinase activity|
|negative regulation of cell cycle phase transition|
|negative regulation of growth|
|negative regulation of kinase activity|
|Ras protein signal transduction|
|mitotic cell cycle phase transition|
|negative regulation of cell adhesion|
|negative regulation of transferase activity|
|aging|
|cell cycle phase transition|
|DNA conformation change|
|negative regulation of mitotic cell cycle|
|small GTPase mediated signal transduction|
|negative regulation of cell cycle process|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|regulation of DNA-binding transcription factor activity|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|protein kinase binding|
|regulation of protein serine/threonine kinase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|mitotic cell cycle|
|positive regulation of cell death|
|chromatin organization|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11924
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDKN2A Expression in NALM6 Cells: -4.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>