CDKN2AIP [The Human Chemical-Genetic Interaction Map Project]

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======= CDKN2AIP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDKN2AIP
  * **<color #00a2e8>Official Name</color>**: CDKN2A interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55602|55602]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NXV6|Q9NXV6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDKN2AIP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDKN2AIP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615914|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. {ECO:0000269|PubMed:15109303, ECO:0000269|PubMed:24825908}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3469|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|granular component|
|p53 binding|
|positive regulation of cell growth|
|negative regulation of cell growth|
|negative regulation of growth|
|positive regulation of growth|
|regulation of protein stability|
|regulation of cell growth|
|regulation of growth|
|cellular response to DNA damage stimulus|
|nucleolus|
|RNA binding|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-3.33|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.49|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.25|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.98|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.94|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.91|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.88|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.79|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.71|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.74|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.75|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.96|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.54|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13339
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDKN2AIP Expression in NALM6 Cells: 5.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>