CDKN2D [The Human Chemical-Genetic Interaction Map Project]

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======= CDKN2D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDKN2D
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase inhibitor 2D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1032|1032]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55273|P55273]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDKN2D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDKN2D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600927|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Interacts strongly with CDK4 and CDK6 and inhibits them. {ECO:0000269|PubMed:7739548, ECO:0000269|PubMed:8741839}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclin D2-CDK4 complex|
|autophagic cell death|
|cyclin-dependent protein serine/threonine kinase inhibitor activity|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|response to vitamin D|
|negative regulation of cyclin-dependent protein kinase activity|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|DNA synthesis involved in DNA repair|
|negative regulation of response to DNA damage stimulus|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|response to vitamin|
|negative regulation of cysteine-type endopeptidase activity|
|negative regulation of intrinsic apoptotic signaling pathway|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of cell cycle G1/S phase transition|
|response to retinoic acid|
|DNA biosynthetic process|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|negative regulation of protein serine/threonine kinase activity|
|response to UV|
|cell cycle arrest|
|sensory perception of sound|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of cell cycle G1/S phase transition|
|sensory perception of mechanical stimulus|
|negative regulation of cell growth|
|negative regulation of mitotic cell cycle phase transition|
|response to nutrient|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|negative regulation of protein kinase activity|
|negative regulation of cell cycle phase transition|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of growth|
|negative regulation of endopeptidase activity|
|negative regulation of kinase activity|
|negative regulation of peptidase activity|
|mitotic cell cycle phase transition|
|negative regulation of transferase activity|
|cell cycle phase transition|
|negative regulation of mitotic cell cycle|
|response to light stimulus|
|negative regulation of cell cycle process|
|response to acid chemical|
|negative regulation of proteolysis|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|regulation of endopeptidase activity|
|regulation of cell growth|
|response to radiation|
|negative regulation of phosphorylation|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|negative regulation of hydrolase activity|
|protein kinase binding|
|response to nutrient levels|
|negative regulation of intracellular signal transduction|
|DNA repair|
|regulation of protein serine/threonine kinase activity|
|response to extracellular stimulus|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|regulation of growth|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|regulation of proteolysis|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|response to lipid|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to organic cyclic compound|
|sensory perception|
|regulation of transferase activity|
|negative regulation of cell death|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15334
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDKN2D Expression in NALM6 Cells: 3.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>