CDON [The Human Chemical-Genetic Interaction Map Project]

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======= CDON =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDON
  * **<color #00a2e8>Official Name</color>**: cell adhesion associated, oncogene regulated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50937|50937]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q4KMG0|Q4KMG0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDON&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDON|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608707|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|fn3|
|ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|skeletal muscle satellite cell differentiation|
|embryonic body morphogenesis|
|embryonic retina morphogenesis in camera-type eye|
|regulation of protein heterodimerization activity|
|myoblast fusion|
|positive regulation of myoblast differentiation|
|positive regulation of skeletal muscle tissue development|
|syncytium formation by plasma membrane fusion|
|cell-cell fusion|
|syncytium formation|
|body morphogenesis|
|regulation of skeletal muscle tissue development|
|retina morphogenesis in camera-type eye|
|skeletal muscle cell differentiation|
|positive regulation of neural precursor cell proliferation|
|regulation of myoblast differentiation|
|myotube differentiation|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|positive regulation of muscle tissue development|
|positive regulation of small GTPase mediated signal transduction|
|smoothened signaling pathway|
|lens development in camera-type eye|
|positive regulation of muscle cell differentiation|
|cell fate specification|
|regulation of neural precursor cell proliferation|
|camera-type eye morphogenesis|
|cerebral cortex development|
|skeletal muscle tissue development|
|regulation of striated muscle tissue development|
|skeletal muscle organ development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|retina development in camera-type eye|
|eye morphogenesis|
|regulation of muscle cell differentiation|
|pallium development|
|striated muscle cell differentiation|
|anterior/posterior pattern specification|
|regulation of protein binding|
|muscle cell differentiation|
|cell fate commitment|
|sensory organ morphogenesis|
|telencephalon development|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|camera-type eye development|
|regionalization|
|regulation of small GTPase mediated signal transduction|
|eye development|
|visual system development|
|collagen-containing extracellular matrix|
|sensory system development|
|positive regulation of neuron differentiation|
|regulation of binding|
|forebrain development|
|pattern specification process|
|positive regulation of neurogenesis|
|muscle structure development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|sensory organ development|
|embryonic morphogenesis|
|regulation of neuron differentiation|
|brain development|
|regulation of MAPK cascade|
|head development|
|regulation of neurogenesis|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.87|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8397
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDON Expression in NALM6 Cells: 5.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>