CEBPB [The Human Chemical-Genetic Interaction Map Project]

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======= CEBPB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEBPB
  * **<color #00a2e8>Official Name</color>**: CCAAT enhancer binding protein beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1051|1051]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17676|P17676]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEBPB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEBPB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189965|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}. Isoform 3: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|bZIP 2|
|bZIP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CHOP-C/EBP complex|
|regulation of odontoblast differentiation|
|positive regulation of sodium-dependent phosphate transport|
|epithelial cell proliferation involved in liver morphogenesis|
|hepatocyte proliferation|
|liver morphogenesis|
|regulation of sodium-dependent phosphate transport|
|condensed chromosome, centromeric region|
|regulation of phosphate transport|
|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|
|mammary gland epithelial cell proliferation|
|regulation of dendritic cell differentiation|
|glucocorticoid receptor binding|
|regulation of transcription involved in cell fate commitment|
|mammary gland epithelial cell differentiation|
|ubiquitin-like protein ligase binding|
|regulation of interleukin-6 biosynthetic process|
|positive regulation of interleukin-4 production|
|regulation of interleukin-4 production|
|brown fat cell differentiation|
|histone acetyltransferase binding|
|liver regeneration|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|RNA polymerase II core promoter sequence-specific DNA binding|
|acute-phase response|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|positive regulation of anion transport|
|ovarian follicle development|
|positive regulation of osteoblast differentiation|
|mammary gland epithelium development|
|negative regulation of T cell proliferation|
|positive regulation of fat cell differentiation|
|regulation of osteoclast differentiation|
|cellular response to amino acid stimulus|
|acute inflammatory response|
|animal organ regeneration|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of leukocyte proliferation|
|positive regulation of ossification|
|embryonic placenta development|
|epithelial cell proliferation|
|female gonad development|
|regulation of biomineral tissue development|
|development of primary female sexual characteristics|
|kinase binding|
|regulation of biomineralization|
|regulation of anion transport|
|positive regulation of cold-induced thermogenesis|
|gland morphogenesis|
|regulation of cytokine biosynthetic process|
|fat cell differentiation|
|female sex differentiation|
|nuclear matrix|
|negative regulation of T cell activation|
|histone deacetylase binding|
|regulation of osteoblast differentiation|
|response to amino acid|
|regulation of myeloid leukocyte differentiation|
|memory|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of fat cell differentiation|
|regulation of DNA-templated transcription in response to stress|
|liver development|
|mammary gland development|
|hepaticobiliary system development|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|regulation of epithelial cell differentiation|
|regulation of cold-induced thermogenesis|
|negative regulation of neuron apoptotic process|
|negative regulation of lymphocyte activation|
|intrinsic apoptotic signaling pathway|
|placenta development|
|regeneration|
|regulation of T cell proliferation|
|negative regulation of leukocyte activation|
|cellular response to interleukin-1|
|negative regulation of cell-cell adhesion|
|cellular response to lipopolysaccharide|
|regulation of ossification|
|cellular response to molecule of bacterial origin|
|negative regulation of cell activation|
|response to interleukin-1|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|cellular response to acid chemical|
|regulation of lymphocyte proliferation|
|gonad development|
|regulation of mononuclear cell proliferation|
|cellular response to biotic stimulus|
|development of primary sexual characteristics|
|regulation of leukocyte proliferation|
|regulation of myeloid cell differentiation|
|nuclear chromatin|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|response to endoplasmic reticulum stress|
|learning or memory|
|sex differentiation|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|positive regulation of ion transport|
|apoptotic signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|cognition|
|regulation of neuron death|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|defense response to bacterium|
|regulation of inflammatory response|
|response to acid chemical|
|in utero embryonic development|
|chromatin binding|
|regulation of cell-cell adhesion|
|gland development|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|positive regulation of defense response|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|inflammatory response|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of lymphocyte activation|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|cell population proliferation|
|behavior|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|chordate embryonic development|
|transcription, DNA-templated|
|regulation of cell activation|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of ion transport|
|regulation of defense response|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to organic cyclic compound|
|apoptotic process|
|defense response to other organism|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|positive regulation of transport|
|negative regulation of cell death|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|neuron differentiation|
|programmed cell death|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5377
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEBPB Expression in NALM6 Cells: 3.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>