CEL [The Human Chemical-Genetic Interaction Map Project]

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======= CEL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEL
  * **<color #00a2e8>Official Name</color>**: carboxyl ester lipase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1056|1056]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19835|P19835]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114840|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 3|
|COesterase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein esterification|
|intestinal lipid catabolic process|
|pancreatic juice secretion|
|sterol esterase activity|
|presynaptic membrane assembly|
|intestinal cholesterol absorption|
|presynaptic membrane organization|
|intestinal lipid absorption|
|postsynaptic membrane assembly|
|cholesterol catabolic process|
|sterol catabolic process|
|neurexin family protein binding|
|lipid digestion|
|neuron cell-cell adhesion|
|presynapse assembly|
|postsynapse assembly|
|secretion by tissue|
|presynapse organization|
|triglyceride lipase activity|
|steroid catabolic process|
|postsynaptic membrane organization|
|intestinal absorption|
|membrane assembly|
|membrane biogenesis|
|synaptic vesicle endocytosis|
|presynaptic endocytosis|
|catalytic activity|
|synaptic vesicle recycling|
|cholesterol transport|
|alcohol catabolic process|
|sterol transport|
|body fluid secretion|
|digestive system process|
|organic hydroxy compound catabolic process|
|hydrolase activity|
|postsynapse organization|
|fatty acid catabolic process|
|synapse assembly|
|presynapse|
|digestion|
|monocarboxylic acid catabolic process|
|cholesterol metabolic process|
|synaptic vesicle cycle|
|secondary alcohol metabolic process|
|vesicle-mediated transport in synapse|
|sterol metabolic process|
|organic hydroxy compound transport|
|heparin binding|
|cellular lipid catabolic process|
|signaling receptor activity|
|steroid metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|synapse|
|synapse organization|
|lipid transport|
|lipid catabolic process|
|alcohol metabolic process|
|lipid localization|
|fatty acid metabolic process|
|small molecule catabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|regulation of body fluid levels|
|cell-cell adhesion|
|monocarboxylic acid metabolic process|
|endocytosis|
|cell surface|
|import into cell|
|membrane organization|
|carboxylic acid metabolic process|
|cell adhesion|
|biological adhesion|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|secretion|
|lipid metabolic process|
|integral component of plasma membrane|
|extracellular space|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10957
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.66 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEL Expression in NALM6 Cells: 0.66'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>