CELF1 [The Human Chemical-Genetic Interaction Map Project]

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======= CELF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CELF1
  * **<color #00a2e8>Official Name</color>**: CUGBP Elav-like family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10658|10658]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92879|Q92879]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CELF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CELF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601074|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre- mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri- MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250, ECO:0000269|PubMed:10536163, ECO:0000269|PubMed:11124939, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:12799066, ECO:0000269|PubMed:14726956, ECO:0000269|PubMed:16601207, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:28431233}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|BRE binding|
|translation repressor activity, mRNA regulatory element binding|
|pre-mRNA binding|
|RNA interference|
|mRNA splice site selection|
|spliceosomal complex assembly|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|regulation of alternative mRNA splicing, via spliceosome|
|gene silencing by RNA|
|regulation of mRNA splicing, via spliceosome|
|negative regulation of translation|
|regulation of RNA splicing|
|regulation of mRNA processing|
|negative regulation of cellular amide metabolic process|
|gene silencing|
|ribonucleoprotein complex|
|mRNA binding|
|ribonucleoprotein complex assembly|
|regulation of gene expression, epigenetic|
|ribonucleoprotein complex subunit organization|
|germ cell development|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|RNA splicing|
|regulation of cellular amide metabolic process|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|posttranscriptional regulation of gene expression|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|gamete generation|
|mRNA metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|RNA processing|
|embryo development|
|multi-organism reproductive process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|reproductive process|
|reproduction|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|cell development|
|RNA metabolic process|
|negative regulation of gene expression|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.7|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.7|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.73|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.75|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.78|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.82|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.82|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.86|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.95|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.98|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.03|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.04|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.06|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.12|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.13|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.17|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.24|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.34|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.37|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.39|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.41|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.45|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.57|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:scaf8|SCAF8]]|0.462|
|[[:human genes:b:brpf1|BRPF1]]|0.448|
|[[:human genes:z:znf592|ZNF592]]|0.44|
|[[:human genes:i:id3|ID3]]|0.439|
|[[:human genes:p:prkar1a|PRKAR1A]]|0.428|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3693
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CELF1 Expression in NALM6 Cells: 7.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>