CENPC [The Human Chemical-Genetic Interaction Map Project]

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======= CENPC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CENPC
  * **<color #00a2e8>Official Name</color>**: centromere protein C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1060|1060]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q03188|Q03188]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CENPC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CENPC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/117141|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cupin 2|
|Mif2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation|
|attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|
|centromeric DNA binding|
|nuclear pericentric heterochromatin|
|condensed nuclear chromosome kinetochore|
|attachment of mitotic spindle microtubules to kinetochore|
|condensed nuclear chromosome, centromeric region|
|kinetochore assembly|
|pericentric heterochromatin|
|kinetochore organization|
|attachment of spindle microtubules to kinetochore|
|Flemming body|
|CENP-A containing chromatin organization|
|CENP-A containing nucleosome assembly|
|chromatin remodeling at centromere|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|mitotic metaphase plate congression|
|histone exchange|
|metaphase plate congression|
|cleavage furrow|
|homologous chromosome segregation|
|intercellular bridge|
|establishment of chromosome localization|
|chromosome localization|
|ATP-dependent chromatin remodeling|
|kinetochore|
|meiotic chromosome segregation|
|mitotic sister chromatid segregation|
|meiosis I|
|meiosis I cell cycle process|
|nucleosome assembly|
|chromatin assembly|
|sister chromatid segregation|
|mitotic nuclear division|
|meiotic nuclear division|
|chromatin assembly or disassembly|
|nucleosome organization|
|midbody|
|chromatin remodeling|
|meiotic cell cycle process|
|DNA packaging|
|protein-DNA complex assembly|
|nuclear chromosome segregation|
|meiotic cell cycle|
|protein-DNA complex subunit organization|
|chromosome segregation|
|nuclear body|
|nuclear division|
|DNA conformation change|
|organelle fission|
|establishment of organelle localization|
|cell division|
|organelle localization|
|mitotic cell cycle process|
|mitotic cell cycle|
|chromatin organization|
|organelle assembly|
|cellular protein-containing complex assembly|
|cell cycle process|
|chromosome organization|
|identical protein binding|
|cell cycle|
|reproductive process|
|reproduction|
|DNA binding|
|protein-containing complex assembly|
|establishment of localization in cell|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.9|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.75|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.73|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.71|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 42/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|3/25|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/15|
|kidney|2/21|
|liver|0/20|
|lung|8/75|
|lymphocyte|1/14|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3031
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CENPC Expression in NALM6 Cells: 6.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>