CENPK [The Human Chemical-Genetic Interaction Map Project]

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======= CENPK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CENPK
  * **<color #00a2e8>Official Name</color>**: centromere protein K
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64105|64105]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BS16|Q9BS16]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CENPK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CENPK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611502|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore. {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18045986}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CENP-K|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|condensed nuclear chromosome inner kinetochore|
|kinetochore assembly|
|kinetochore organization|
|CENP-A containing nucleosome assembly|
|CENP-A containing chromatin organization|
|chromatin remodeling at centromere|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|histone exchange|
|ATP-dependent chromatin remodeling|
|mitotic sister chromatid segregation|
|nucleosome assembly|
|chromatin assembly|
|sister chromatid segregation|
|mitotic nuclear division|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|DNA packaging|
|protein-DNA complex assembly|
|nuclear chromosome segregation|
|protein-DNA complex subunit organization|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|organelle fission|
|mitotic cell cycle process|
|mitotic cell cycle|
|chromatin organization|
|organelle assembly|
|cellular protein-containing complex assembly|
|cell cycle process|
|chromosome organization|
|cell cycle|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-2.18|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.89|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.88|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.79|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.73|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.7|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 695/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|23/25|
|breast|33/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|14/15|
|kidney|19/21|
|liver|20/20|
|lung|71/75|
|lymphocyte|12/14|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 602
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CENPK Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>