CEP55 [The Human Chemical-Genetic Interaction Map Project]

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======= CEP55 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEP55
  * **<color #00a2e8>Official Name</color>**: centrosomal protein 55
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55165|55165]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53EZ4|Q53EZ4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEP55&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEP55|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610000|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:28264986}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EABR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|midbody abscission|
|mitotic cytokinetic process|
|Flemming body|
|cytokinetic process|
|mitotic metaphase plate congression|
|metaphase plate congression|
|cleavage furrow|
|intercellular bridge|
|cranial skeletal system development|
|mitotic cytokinesis|
|establishment of chromosome localization|
|chromosome localization|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|mitotic sister chromatid segregation|
|regulation of phosphatidylinositol 3-kinase signaling|
|nucleus organization|
|centriole|
|sister chromatid segregation|
|mitotic nuclear division|
|microtubule organizing center|
|midbody|
|nuclear chromosome segregation|
|chromosome segregation|
|renal system development|
|nuclear division|
|organelle fission|
|urogenital system development|
|establishment of organelle localization|
|centrosome|
|cell division|
|organelle localization|
|mitotic cell cycle process|
|mitotic cell cycle|
|membrane organization|
|cell cycle process|
|chromosome organization|
|cell cycle|
|establishment of protein localization|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.86|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.74|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.74|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.71|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.73|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.86|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr87|WDR87]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 25/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|3/26|
|breast|1/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2084
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEP55 Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>