CETP [The Human Chemical-Genetic Interaction Map Project]

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======= CETP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CETP
  * **<color #00a2e8>Official Name</color>**: cholesteryl ester transfer protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1071|1071]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11597|P11597]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CETP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CETP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796). {ECO:0000269|PubMed:24293641, ECO:0000303|PubMed:17237796, ECO:0000305|PubMed:3600759}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LBP BPI CETP C|
|LBP BPI CETP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|triglyceride binding|
|acylglycerol transport|
|triglyceride transport|
|very-low-density lipoprotein particle remodeling|
|phospholipid homeostasis|
|negative regulation of macrophage derived foam cell differentiation|
|low-density lipoprotein particle remodeling|
|triglyceride-rich lipoprotein particle remodeling|
|reverse cholesterol transport|
|phospholipid transporter activity|
|high-density lipoprotein particle remodeling|
|cholesterol transfer activity|
|high-density lipoprotein particle|
|regulation of cholesterol efflux|
|phosphatidylcholine binding|
|plasma lipoprotein particle remodeling|
|protein-lipid complex remodeling|
|protein-containing complex remodeling|
|regulation of macrophage derived foam cell differentiation|
|lipid transporter activity|
|triglyceride homeostasis|
|acylglycerol homeostasis|
|plasma lipoprotein particle organization|
|regulation of cholesterol transport|
|regulation of sterol transport|
|protein-lipid complex subunit organization|
|cholesterol binding|
|cholesterol transport|
|anion homeostasis|
|sterol transport|
|regulation of plasma lipoprotein particle levels|
|triglyceride metabolic process|
|phosphatidylcholine metabolic process|
|cholesterol homeostasis|
|sterol homeostasis|
|phospholipid transport|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|regulation of lipid transport|
|cholesterol metabolic process|
|organophosphate ester transport|
|secondary alcohol metabolic process|
|lipid homeostasis|
|sterol metabolic process|
|regulation of lipid localization|
|organic hydroxy compound transport|
|vesicle|
|lipid binding|
|ammonium ion metabolic process|
|steroid metabolic process|
|lipid transport|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|lipid localization|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|extracellular structure organization|
|organic hydroxy compound metabolic process|
|organic anion transport|
|anion transport|
|negative regulation of cell differentiation|
|ion homeostasis|
|organophosphate metabolic process|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|chemical homeostasis|
|lipid metabolic process|
|ion transport|
|extracellular space|
|homeostatic process|
|small molecule metabolic process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11410
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CETP Expression in NALM6 Cells: 0.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>