CHCHD4 [The Human Chemical-Genetic Interaction Map Project]

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======= CHCHD4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHCHD4
  * **<color #00a2e8>Official Name</color>**: coiled-coil-helix-coiled-coil-helix domain containing 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=131474|131474]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N4Q1|Q8N4Q1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHCHD4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHCHD4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611077|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1 (PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS) (PubMed:16185709, PubMed:19182799, PubMed:21059946). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria (PubMed:16185709, PubMed:19182799, PubMed:21059946). The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864). {ECO:0000269|PubMed:16185709, ECO:0000269|PubMed:19182799, ECO:0000269|PubMed:21059946, ECO:0000269|PubMed:23186364, ECO:0000269|PubMed:26387864}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CHCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein import into mitochondrial intermembrane space|
|peptidyl-cysteine oxidation|
|protein maturation by protein folding|
|protein oxidation|
|protein disulfide oxidoreductase activity|
|protein transmembrane import into intracellular organelle|
|de novo posttranslational protein folding|
|peptidyl-cysteine modification|
|de novo protein folding|
|intracellular protein transmembrane transport|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial intermembrane space|
|mitochondrial transmembrane transport|
|protein import|
|mitochondrial transport|
|protein maturation|
|protein folding|
|protein targeting|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to organelle|
|peptidyl-amino acid modification|
|oxidation-reduction process|
|intracellular protein transport|
|mitochondrion|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.1|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.83|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.82|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.72|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.71|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.75|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.84|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.95|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.03|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.13|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:triap1|TRIAP1]]|0.564|
|[[:human genes:m:mrps34|MRPS34]]|0.56|
|[[:human genes:m:mrpl21|MRPL21]]|0.553|
|[[:human genes:g:gmppb|GMPPB]]|0.55|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.548|
|[[:human genes:r:rpia|RPIA]]|0.546|
|[[:human genes:h:hars|HARS]]|0.542|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.536|
|[[:human genes:p:pmm2|PMM2]]|0.536|
|[[:human genes:m:mrp63|MRP63]]|0.532|
|[[:human genes:t:thg1l|THG1L]]|0.532|
|[[:human genes:s:srp14|SRP14]]|0.53|
|[[:human genes:s:sars2|SARS2]]|0.53|
|[[:human genes:m:mrpl15|MRPL15]]|0.529|
|[[:human genes:r:rpusd4|RPUSD4]]|0.527|
|[[:human genes:y:yars2|YARS2]]|0.523|
|[[:human genes:m:mrps18a|MRPS18A]]|0.523|
|[[:human genes:m:mrpl23|MRPL23]]|0.521|
|[[:human genes:u:uap1|UAP1]]|0.52|
|[[:human genes:p:pdss1|PDSS1]]|0.52|
|[[:human genes:f:fastkd5|FASTKD5]]|0.519|
|[[:human genes:m:mrps5|MRPS5]]|0.515|
|[[:human genes:d:dhrsx|DHRSX]]|0.512|
|[[:human genes:a:alg13|ALG13]]|0.511|
|[[:human genes:b:bcs1l|BCS1L]]|0.508|
|[[:human genes:p:ppa2|PPA2]]|0.507|
|[[:human genes:t:ten1|TEN1]]|0.507|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.505|
|[[:human genes:m:mrps2|MRPS2]]|0.503|
|[[:human genes:m:mrps14|MRPS14]]|0.502|
|[[:human genes:m:mrps6|MRPS6]]|0.502|
|[[:human genes:d:dpagt1|DPAGT1]]|0.501|
|[[:human genes:t:taz|TAZ]]|0.5|
|[[:human genes:u:uqcr10|UQCR10]]|0.5|
|[[:human genes:l:lsm10|LSM10]]|0.499|
|[[:human genes:m:mrps33|MRPS33]]|0.496|
|[[:human genes:m:mrpl53|MRPL53]]|0.496|
|[[:human genes:v:vezt|VEZT]]|0.494|
|[[:human genes:t:tamm41|TAMM41]]|0.493|
|[[:human genes:t:tufm|TUFM]]|0.492|
|[[:human genes:g:gfm1|GFM1]]|0.49|
|[[:human genes:g:gemin7|GEMIN7]]|0.489|
|[[:human genes:m:mrps9|MRPS9]]|0.488|
|[[:human genes:c:cox16|COX16]]|0.488|
|[[:human genes:t:tars2|TARS2]]|0.487|
|[[:human genes:a:adsl|ADSL]]|0.487|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.485|
|[[:human genes:d:dars2|DARS2]]|0.485|
|[[:human genes:u:uhrf1|UHRF1]]|0.483|
|[[:human genes:s:slc25a26|SLC25A26]]|0.482|
|[[:human genes:c:c17orf89|C17orf89]]|0.48|
|[[:human genes:a:atxn10|ATXN10]]|0.477|
|[[:human genes:e:eif3f|EIF3F]]|0.476|
|[[:human genes:m:mrps16|MRPS16]]|0.475|
|[[:human genes:r:rpe|RPE]]|0.474|
|[[:human genes:m:mrps23|MRPS23]]|0.473|
|[[:human genes:a:atic|ATIC]]|0.472|
|[[:human genes:m:mrps24|MRPS24]]|0.472|
|[[:human genes:p:pik3r4|PIK3R4]]|0.472|
|[[:human genes:m:mrps26|MRPS26]]|0.471|
|[[:human genes:d:dap3|DAP3]]|0.471|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.471|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.47|
|[[:human genes:c:c12orf65|C12orf65]]|0.47|
|[[:human genes:p:ppcs|PPCS]]|0.469|
|[[:human genes:t:txnl4b|TXNL4B]]|0.468|
|[[:human genes:s:sco2|SCO2]]|0.468|
|[[:human genes:p:polg|POLG]]|0.467|
|[[:human genes:f:fh|FH]]|0.467|
|[[:human genes:e:elac2|ELAC2]]|0.467|
|[[:human genes:a:alg1|ALG1]]|0.466|
|[[:human genes:h:hccs|HCCS]]|0.465|
|[[:human genes:t:trnt1|TRNT1]]|0.465|
|[[:human genes:r:rbfa|RBFA]]|0.465|
|[[:human genes:e:ears2|EARS2]]|0.461|
|[[:human genes:m:mrps11|MRPS11]]|0.461|
|[[:human genes:p:ptdss1|PTDSS1]]|0.461|
|[[:human genes:m:mrps21|MRPS21]]|0.459|
|[[:human genes:c:cbfb|CBFB]]|0.459|
|[[:human genes:g:gemin8|GEMIN8]]|0.454|
|[[:human genes:m:mtpap|MTPAP]]|0.454|
|[[:human genes:n:nae1|NAE1]]|0.451|
|[[:human genes:c:c10orf2|C10orf2]]|0.451|
|[[:human genes:s:selrc1|SELRC1]]|0.451|
|[[:human genes:t:tpk1|TPK1]]|0.45|
|[[:human genes:t:tma16|TMA16]]|0.45|
|[[:human genes:r:rabggtb|RABGGTB]]|0.45|
|[[:human genes:n:nbn|NBN]]|0.449|
|[[:human genes:c:cox5a|COX5A]]|0.449|
|[[:human genes:n:ndufa3|NDUFA3]]|0.447|
|[[:human genes:p:pggt1b|PGGT1B]]|0.446|
|[[:human genes:c:cox6c|COX6C]]|0.445|
|[[:human genes:r:rbmx2|RBMX2]]|0.444|
|[[:human genes:m:mrpl47|MRPL47]]|0.443|
|[[:human genes:t:tmem242|TMEM242]]|0.442|
|[[:human genes:h:haus8|HAUS8]]|0.441|
|[[:human genes:a:alg8|ALG8]]|0.441|
|[[:human genes:n:ndufb5|NDUFB5]]|0.44|
|[[:human genes:g:gfpt1|GFPT1]]|0.44|
|[[:human genes:p:pars2|PARS2]]|0.44|
|[[:human genes:r:rnmt|RNMT]]|0.44|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.44|
|[[:human genes:g:gemin6|GEMIN6]]|0.44|
|[[:human genes:m:mtg2|MTG2]]|0.439|
|[[:human genes:a:alg6|ALG6]]|0.438|
|[[:human genes:r:rptor|RPTOR]]|0.437|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.436|
|[[:human genes:s:sdha|SDHA]]|0.435|
|[[:human genes:f:fnta|FNTA]]|0.434|
|[[:human genes:t:tefm|TEFM]]|0.434|
|[[:human genes:d:dhps|DHPS]]|0.433|
|[[:human genes:v:vars2|VARS2]]|0.432|
|[[:human genes:d:dohh|DOHH]]|0.431|
|[[:human genes:m:mrpl34|MRPL34]]|0.43|
|[[:human genes:a:atp5d|ATP5D]]|0.429|
|[[:human genes:s:sec62|SEC62]]|0.428|
|[[:human genes:s:stt3a|STT3A]]|0.427|
|[[:human genes:a:atp5j|ATP5J]]|0.427|
|[[:human genes:b:bap1|BAP1]]|0.426|
|[[:human genes:p:pgm3|PGM3]]|0.425|
|[[:human genes:t:tomm40|TOMM40]]|0.423|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.423|
|[[:human genes:r:rpp21|RPP21]]|0.421|
|[[:human genes:d:ddx20|DDX20]]|0.421|
|[[:human genes:a:atp5b|ATP5B]]|0.417|
|[[:human genes:u:uqcrq|UQCRQ]]|0.417|
|[[:human genes:l:lsm11|LSM11]]|0.416|
|[[:human genes:n:ndufb1|NDUFB1]]|0.416|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.416|
|[[:human genes:t:timm8b|TIMM8B]]|0.416|
|[[:human genes:m:mrpl12|MRPL12]]|0.415|
|[[:human genes:u:uqcc2|UQCC2]]|0.412|
|[[:human genes:s:sec61g|SEC61G]]|0.411|
|[[:human genes:r:rtcb|RTCB]]|0.411|
|[[:human genes:s:slc25a19|SLC25A19]]|0.411|
|[[:human genes:d:dhx30|DHX30]]|0.41|
|[[:human genes:c:cox17|COX17]]|0.41|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.41|
|[[:human genes:r:rad1|RAD1]]|0.41|
|[[:human genes:d:dolk|DOLK]]|0.41|
|[[:human genes:u:utp23|UTP23]]|0.409|
|[[:human genes:t:tmem126b|TMEM126B]]|0.409|
|[[:human genes:k:kdsr|KDSR]]|0.409|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.408|
|[[:human genes:r:romo1|ROMO1]]|0.408|
|[[:human genes:p:pelo|PELO]]|0.407|
|[[:human genes:t:trmt61a|TRMT61A]]|0.407|
|[[:human genes:m:mbtps2|MBTPS2]]|0.406|
|[[:human genes:u:uxt|UXT]]|0.406|
|[[:human genes:m:mrpl20|MRPL20]]|0.405|
|[[:human genes:y:yars|YARS]]|0.405|
|[[:human genes:t:tprkb|TPRKB]]|0.404|
|[[:human genes:m:mtor|MTOR]]|0.404|
|[[:human genes:c:cbx3|CBX3]]|0.403|
|[[:human genes:c:cox7b|COX7B]]|0.403|
|[[:human genes:c:coa6|COA6]]|0.403|
|[[:human genes:p:ppp4c|PPP4C]]|0.403|
|[[:human genes:m:mrpl55|MRPL55]]|0.402|
|[[:human genes:t:ttc4|TTC4]]|0.402|
|[[:human genes:n:nsmce1|NSMCE1]]|0.402|
|[[:human genes:c:crls1|CRLS1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 471/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|21/28|
|blood|7/28|
|bone|19/26|
|breast|14/33|
|central nervous system|39/56|
|cervix|4/4|
|colorectal|12/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|16/21|
|liver|14/20|
|lung|53/75|
|lymphocyte|5/16|
|ovary|15/26|
|pancreas|18/24|
|peripheral nervous system|12/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|14/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|20/22|
|urinary tract|20/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7667
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHCHD4 Expression in NALM6 Cells: 4.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>