CHD1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= CHD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHD1
  * **<color #00a2e8>Official Name</color>**: chromodomain helicase DNA binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1105|1105]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14646|O14646]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602118|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells. {ECO:0000250, ECO:0000269|PubMed:18042460}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNF2 N|
|Helicase C|
|Chromo|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation by host of viral transcription|
|positive regulation of viral transcription|
|DNA helicase activity|
|methylated histone binding|
|regulation of viral transcription|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|positive regulation of viral process|
|DNA duplex unwinding|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|DNA geometric change|
|fibrillar center|
|modification of morphology or physiology of other organism|
|chromatin remodeling|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|DNA conformation change|
|covalent chromatin modification|
|positive regulation of multi-organism process|
|chromatin organization|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|chromosome organization|
|DNA binding|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-3.22|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-3.01|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-2.19|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.18|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.14|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.95|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.95|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.94|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.93|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.91|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.76|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.76|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.75|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.75|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.74|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.74|
|[[:results:exp303|39°C R06 exp303]]|1.88|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.95|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.01|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.08|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.4|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.58|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.97|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|3.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18037
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHD1 Expression in NALM6 Cells: 7.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>