CHD2 [The Human Chemical-Genetic Interaction Map Project]

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======= CHD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHD2
  * **<color #00a2e8>Official Name</color>**: chromodomain helicase DNA binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1106|1106]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14647|O14647]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602119|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Chromo|
|Helicase C|
|SNF2 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hematopoietic stem cell differentiation|
|DNA helicase activity|
|hematopoietic progenitor cell differentiation|
|DNA duplex unwinding|
|DNA geometric change|
|histone binding|
|stem cell differentiation|
|muscle organ development|
|DNA conformation change|
|muscle structure development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|intracellular membrane-bounded organelle|
|chromatin organization|
|cellular response to DNA damage stimulus|
|nucleolus|
|chromosome organization|
|RNA binding|
|DNA binding|
|ATP binding|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.04|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.89|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.85|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.78|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.72|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.7|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.71|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.73|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.75|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.79|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.79|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.82|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.95|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.03|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.03|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.04|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.1|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.2|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.24|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.27|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.39|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.82|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|3.07|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|3.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3485
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHD2 Expression in NALM6 Cells: 8.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>