CHERP [The Human Chemical-Genetic Interaction Map Project]

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======= CHERP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHERP
  * **<color #00a2e8>Official Name</color>**: calcium homeostasis endoplasmic reticulum protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10523|10523]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWX8|Q8IWX8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHERP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHERP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618539|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Surp|
|DUF618|
|G-patch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of calcineurin-mediated signaling|
|positive regulation of calcineurin-NFAT signaling cascade|
|sarcoplasmic reticulum membrane|
|regulation of calcineurin-mediated signaling|
|regulation of calcineurin-NFAT signaling cascade|
|positive regulation of calcium-mediated signaling|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|calcium ion transmembrane import into cytosol|
|calcium ion transport into cytosol|
|cytosolic calcium ion transport|
|regulation of calcium-mediated signaling|
|regulation of sequestering of calcium ion|
|ion channel binding|
|calcium ion transmembrane transport|
|calcium ion transport|
|positive regulation of cytosolic calcium ion concentration|
|divalent metal ion transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|RNA splicing|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|mRNA processing|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|negative regulation of cell population proliferation|
|mRNA metabolic process|
|perinuclear region of cytoplasm|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|RNA processing|
|cellular homeostasis|
|ion transmembrane transport|
|positive regulation of intracellular signal transduction|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|RNA binding|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.06|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.98|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.88|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.8|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.73|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.73|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.72|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.72|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.92|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 707/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|30/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|19/20|
|lung|73/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 905
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHERP Expression in NALM6 Cells: 6.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>