CHMP2A [The Human Chemical-Genetic Interaction Map Project]

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======= CHMP2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHMP2A
  * **<color #00a2e8>Official Name</color>**: charged multivesicular body protein 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27243|27243]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43633|O43633]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHMP2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHMP2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610893|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. {ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:26040712, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Snf7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of centriole elongation|
|regulation of centriole elongation|
|membrane coat|
|negative regulation of centriole replication|
|ESCRT III complex|
|ESCRT III complex disassembly|
|ESCRT complex disassembly|
|negative regulation of centrosome duplication|
|exit from mitosis|
|negative regulation of centrosome cycle|
|positive regulation of exosomal secretion|
|positive regulation of viral release from host cell|
|midbody abscission|
|late endosome to vacuole transport|
|nuclear envelope reassembly|
|regulation of exosomal secretion|
|viral budding via host ESCRT complex|
|mitotic cytokinetic process|
|regulation of centriole replication|
|regulation of mitotic spindle assembly|
|viral budding|
|endosome transport via multivesicular body sorting pathway|
|phosphatidylcholine binding|
|regulation of spindle assembly|
|multivesicular body assembly|
|multivesicular body organization|
|regulation of viral release from host cell|
|multivesicular body|
|multivesicular body sorting pathway|
|cytokinetic process|
|virion assembly|
|negative regulation of organelle assembly|
|regulation of mitotic spindle organization|
|regulation of centrosome duplication|
|regulation of spindle organization|
|mitotic metaphase plate congression|
|nuclear envelope organization|
|metaphase plate congression|
|regulation of centrosome cycle|
|positive regulation of viral life cycle|
|mitotic cytokinesis|
|establishment of chromosome localization|
|chromosome localization|
|endosome organization|
|protein polymerization|
|positive regulation of exocytosis|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|protein heterooligomerization|
|positive regulation of viral process|
|mitotic sister chromatid segregation|
|chromatin|
|late endosome membrane|
|nucleus organization|
|negative regulation of cytoskeleton organization|
|sister chromatid segregation|
|vacuolar transport|
|regulation of viral life cycle|
|membrane invagination|
|mitotic nuclear division|
|macroautophagy|
|regulation of mitotic nuclear division|
|nuclear envelope|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|viral life cycle|
|regulation of viral process|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of microtubule-based process|
|regulation of exocytosis|
|endosomal transport|
|protein-containing complex disassembly|
|protein domain specific binding|
|process utilizing autophagic mechanism|
|autophagy|
|mitotic cell cycle phase transition|
|chromosome segregation|
|cell cycle phase transition|
|nuclear division|
|vesicle organization|
|organelle fission|
|negative regulation of cell cycle process|
|protein homooligomerization|
|establishment of organelle localization|
|negative regulation of organelle organization|
|cellular component disassembly|
|positive regulation of secretion by cell|
|endomembrane system organization|
|positive regulation of secretion|
|cell division|
|positive regulation of multi-organism process|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|negative regulation of cell cycle|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|viral process|
|negative regulation of cellular component organization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|organelle assembly|
|regulation of multi-organism process|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|membrane organization|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|regulation of cell death|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-4.14|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.82|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.74|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.61|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.56|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.52|
|[[:results:exp539|42°C R08 exp539]]|-2.37|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.27|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.27|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.12|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.1|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.09|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.07|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.05|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.05|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.04|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.98|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.95|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.88|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.86|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.84|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.83|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.82|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.78|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.78|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.73|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.72|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.9|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:s1pr4|S1PR4]]|0.509|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.502|
|[[:human genes:m:mt1e|MT1E]]|0.492|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.491|
|[[:human genes:s:ssh2|SSH2]]|0.482|
|[[:human genes:c:c14orf93|C14orf93]]|0.482|
|[[:human genes:r:rad21|RAD21]]|0.48|
|[[:human genes:n:nbpf10|NBPF10]]|0.48|
|[[:human genes:s:scaf1|SCAF1]]|0.474|
|[[:human genes:t:tfip11|TFIP11]]|0.472|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.468|
|[[:human genes:s:smg7|SMG7]]|0.465|
|[[:human genes:r:rps2|RPS2]]|0.464|
|[[:human genes:z:zfand5|ZFAND5]]|0.461|
|[[:human genes:r:rrn3|RRN3]]|0.46|
|[[:human genes:p:pbxip1|PBXIP1]]|0.455|
|[[:human genes:c:chd4|CHD4]]|0.45|
|[[:human genes:v:vasn|VASN]]|0.448|
|[[:human genes:p:psmd1|PSMD1]]|0.448|
|[[:human genes:d:ddtl|DDTL]]|0.447|
|[[:human genes:p:psmc1|PSMC1]]|0.446|
|[[:human genes:p:psmb2|PSMB2]]|0.443|
|[[:human genes:p:polr1a|POLR1A]]|0.442|
|[[:human genes:r:rbm39|RBM39]]|0.441|
|[[:human genes:r:rrm1|RRM1]]|0.44|
|[[:human genes:m:myo1h|MYO1H]]|0.44|
|[[:human genes:p:psmb4|PSMB4]]|0.44|
|[[:human genes:g:gar1|GAR1]]|0.44|
|[[:human genes:m:med12|MED12]]|0.439|
|[[:human genes:r:rrp15|RRP15]]|0.439|
|[[:human genes:d:dtl|DTL]]|0.437|
|[[:human genes:p:psmc6|PSMC6]]|0.437|
|[[:human genes:m:med14|MED14]]|0.435|
|[[:human genes:n:nupl1|NUPL1]]|0.432|
|[[:human genes:p:psmd6|PSMD6]]|0.431|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.431|
|[[:human genes:c:cdc73|CDC73]]|0.43|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.43|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.43|
|[[:human genes:a:aqr|AQR]]|0.429|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.429|
|[[:human genes:o:orc6|ORC6]]|0.429|
|[[:human genes:p:psmd11|PSMD11]]|0.429|
|[[:human genes:a:acsf2|ACSF2]]|0.428|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.428|
|[[:human genes:c:ccna2|CCNA2]]|0.428|
|[[:human genes:a:ahctf1|AHCTF1]]|0.427|
|[[:human genes:c:cdc6|CDC6]]|0.426|
|[[:human genes:c:cbwd3|CBWD3]]|0.426|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.426|
|[[:human genes:s:syt9|SYT9]]|0.425|
|[[:human genes:k:kctd17|KCTD17]]|0.42|
|[[:human genes:o:orc1|ORC1]]|0.418|
|[[:human genes:c:cactin|CACTIN]]|0.417|
|[[:human genes:z:znf675|ZNF675]]|0.417|
|[[:human genes:g:gbf1|GBF1]]|0.416|
|[[:human genes:c:copb1|COPB1]]|0.416|
|[[:human genes:z:znf106|ZNF106]]|0.415|
|[[:human genes:l:lrr1|LRR1]]|0.415|
|[[:human genes:n:nup43|NUP43]]|0.415|
|[[:human genes:t:timeless|TIMELESS]]|0.415|
|[[:human genes:g:gon4l|GON4L]]|0.412|
|[[:human genes:p:psma7|PSMA7]]|0.411|
|[[:human genes:p:psma6|PSMA6]]|0.411|
|[[:human genes:c:cdt1|CDT1]]|0.41|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.409|
|[[:human genes:a:aaas|AAAS]]|0.409|
|[[:human genes:r:rpl35|RPL35]]|0.409|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.408|
|[[:human genes:p:pan2|PAN2]]|0.408|
|[[:human genes:s:supt6h|SUPT6H]]|0.407|
|[[:human genes:m:mdm2|MDM2]]|0.407|
|[[:human genes:p:psma1|PSMA1]]|0.407|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.406|
|[[:human genes:m:myo18a|MYO18A]]|0.406|
|[[:human genes:t:tagln|TAGLN]]|0.405|
|[[:human genes:r:rad51|RAD51]]|0.405|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.404|
|[[:human genes:s:supt5h|SUPT5H]]|0.404|
|[[:human genes:p:plk1|PLK1]]|0.404|
|[[:human genes:r:riok2|RIOK2]]|0.404|
|[[:human genes:p:psmc2|PSMC2]]|0.403|
|[[:human genes:a:abt1|ABT1]]|0.403|
|[[:human genes:a:atxn1|ATXN1]]|0.403|
|[[:human genes:u:ubap1|UBAP1]]|0.402|
|[[:human genes:g:golga8o|GOLGA8O]]|0.402|
|[[:human genes:t:ticrr|TICRR]]|0.401|
|[[:human genes:h:hivep3|HIVEP3]]|0.401|
|[[:human genes:e:exosc9|EXOSC9]]|0.401|
|[[:human genes:c:cbwd5|CBWD5]]|0.4|
|[[:human genes:c:cbwd6|CBWD6]]|0.4|
|[[:human genes:g:gpx4|GPX4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 717/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|19/21|
|liver|19/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|21/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 309
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHMP2A Expression in NALM6 Cells: 4.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>