CHMP2B [The Human Chemical-Genetic Interaction Map Project]

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======= CHMP2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHMP2B
  * **<color #00a2e8>Official Name</color>**: charged multivesicular body protein 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25978|25978]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQN3|Q9UQN3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHMP2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHMP2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609512|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Snf7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|multivesicular body-lysosome fusion|
|endosome to lysosome transport via multivesicular body sorting pathway|
|regulation of modification of postsynaptic structure|
|ESCRT III complex|
|ESCRT complex disassembly|
|ESCRT III complex disassembly|
|regulation of modification of synaptic structure|
|positive regulation of viral release from host cell|
|midbody abscission|
|late endosome to vacuole transport|
|mitotic cytokinetic process|
|viral budding via host ESCRT complex|
|regulation of mitotic spindle assembly|
|endosome transport via multivesicular body sorting pathway|
|viral budding|
|regulation of spindle assembly|
|multivesicular body assembly|
|regulation of viral release from host cell|
|multivesicular body organization|
|multivesicular body|
|neuron cellular homeostasis|
|multivesicular body sorting pathway|
|cytokinetic process|
|virion assembly|
|regulation of mitotic spindle organization|
|regulation of centrosome duplication|
|regulation of spindle organization|
|mitotic metaphase plate congression|
|endosome to lysosome transport|
|metaphase plate congression|
|regulation of centrosome cycle|
|positive regulation of viral life cycle|
|mitotic cytokinesis|
|establishment of chromosome localization|
|chromosome localization|
|endosome organization|
|organelle membrane fusion|
|intracellular|
|organelle fusion|
|regulation of postsynapse organization|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|lysosomal transport|
|positive regulation of viral process|
|mitotic sister chromatid segregation|
|late endosome membrane|
|late endosome|
|membrane fusion|
|nucleus organization|
|vacuolar transport|
|sister chromatid segregation|
|regulation of viral life cycle|
|mitotic nuclear division|
|macroautophagy|
|regulation of mitotic nuclear division|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|viral life cycle|
|regulation of viral process|
|regulation of synapse organization|
|nuclear chromosome segregation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|regulation of synapse structure or activity|
|endosomal transport|
|protein-containing complex disassembly|
|protein domain specific binding|
|lysosome|
|postsynaptic density|
|process utilizing autophagic mechanism|
|autophagy|
|endosome|
|chromosome segregation|
|nuclear division|
|cognition|
|vesicle organization|
|cadherin binding|
|organelle fission|
|anatomical structure homeostasis|
|glutamatergic synapse|
|establishment of organelle localization|
|cellular component disassembly|
|endomembrane system organization|
|cell division|
|positive regulation of multi-organism process|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|viral process|
|regulation of cell cycle process|
|organelle assembly|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|membrane organization|
|cellular homeostasis|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|nervous system process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.86|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.74|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.71|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.435|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18523
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHMP2B Expression in NALM6 Cells: 4.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>