CHMP5 [The Human Chemical-Genetic Interaction Map Project]

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======= CHMP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHMP5
  * **<color #00a2e8>Official Name</color>**: charged multivesicular body protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51510|51510]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZZ3|Q9NZZ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHMP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHMP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610900|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. {ECO:0000269|PubMed:14519844}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Snf7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to muramyl dipeptide|
|ESCRT III complex disassembly|
|ESCRT complex disassembly|
|midbody abscission|
|response to muramyl dipeptide|
|mitotic cytokinetic process|
|regulation of mitotic spindle assembly|
|regulation of receptor recycling|
|viral budding|
|regulation of spindle assembly|
|multivesicular body assembly|
|multivesicular body organization|
|multivesicular body sorting pathway|
|cytokinetic process|
|virion assembly|
|regulation of mitotic spindle organization|
|regulation of centrosome duplication|
|regulation of spindle organization|
|mitotic metaphase plate congression|
|endosome to lysosome transport|
|metaphase plate congression|
|regulation of centrosome cycle|
|lytic vacuole organization|
|lysosome organization|
|mitotic cytokinesis|
|establishment of chromosome localization|
|chromosome localization|
|endosome organization|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|lysosomal transport|
|mitotic sister chromatid segregation|
|vacuole organization|
|nucleus organization|
|sister chromatid segregation|
|vacuolar transport|
|mitotic nuclear division|
|regulation of mitotic nuclear division|
|cellular response to lipopolysaccharide|
|regulation of microtubule cytoskeleton organization|
|cellular response to molecule of bacterial origin|
|regulation of nuclear division|
|viral life cycle|
|endosome membrane|
|cellular response to biotic stimulus|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|endosomal transport|
|protein-containing complex disassembly|
|chromosome segregation|
|nuclear division|
|vesicle organization|
|cadherin binding|
|organelle fission|
|response to lipopolysaccharide|
|cellular response to peptide|
|response to molecule of bacterial origin|
|establishment of organelle localization|
|cellular component disassembly|
|cellular response to drug|
|endomembrane system organization|
|response to peptide|
|cell division|
|cellular response to lipid|
|regulation of cytoskeleton organization|
|organelle localization|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|regulation of mitotic cell cycle|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|response to bacterium|
|viral process|
|regulation of cell cycle process|
|organelle assembly|
|symbiotic process|
|interspecies interaction between organisms|
|membrane organization|
|response to lipid|
|regulation of cellular component biogenesis|
|cell cycle process|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|chromosome organization|
|response to nitrogen compound|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2.64|
|[[:results:exp539|42°C R08 exp539]]|-2.16|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.08|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.02|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.98|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.87|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.82|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.8|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 519/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|22/28|
|bone|12/26|
|breast|21/33|
|central nervous system|30/56|
|cervix|2/4|
|colorectal|8/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|18/21|
|liver|15/20|
|lung|52/75|
|lymphocyte|12/16|
|ovary|20/26|
|pancreas|17/24|
|peripheral nervous system|7/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|21/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|18/22|
|urinary tract|25/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5640
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHMP5 Expression in NALM6 Cells: 4.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>