CHMP7 [The Human Chemical-Genetic Interaction Map Project]

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======= CHMP7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHMP7
  * **<color #00a2e8>Official Name</color>**: charged multivesicular body protein 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91782|91782]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUX9|Q8WUX9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHMP7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHMP7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Snf7|
|PspA IM30|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ESCRT III complex|
|ESCRT complex disassembly|
|ESCRT III complex disassembly|
|exit from mitosis|
|midbody abscission|
|late endosome to vacuole transport|
|nuclear envelope reassembly|
|mitotic cytokinetic process|
|viral budding via host ESCRT complex|
|protein localization to chromatin|
|viral budding|
|multivesicular body assembly|
|multivesicular body organization|
|cytokinetic process|
|virion assembly|
|mitotic metaphase plate congression|
|nuclear envelope organization|
|metaphase plate congression|
|protein localization to chromosome|
|mitotic cytokinesis|
|establishment of chromosome localization|
|chromosome localization|
|endosome organization|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|mitotic sister chromatid segregation|
|chromatin|
|nucleus organization|
|vacuolar transport|
|sister chromatid segregation|
|mitotic nuclear division|
|nuclear envelope|
|viral life cycle|
|nuclear chromosome segregation|
|endosomal transport|
|protein-containing complex disassembly|
|mitotic cell cycle phase transition|
|chromosome segregation|
|cell cycle phase transition|
|nuclear division|
|vesicle organization|
|organelle fission|
|establishment of organelle localization|
|cellular component disassembly|
|endomembrane system organization|
|cell division|
|organelle localization|
|mitotic cell cycle process|
|mitotic cell cycle|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|interspecies interaction between organisms|
|membrane organization|
|cell cycle process|
|chromosome organization|
|cell cycle|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp359|FK-506 30μM R07 exp359]]|-3.19|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.93|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.71|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.53|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.49|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.38|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.37|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.37|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.31|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.27|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.21|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.19|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.09|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.09|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.05|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.03|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.97|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.95|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.92|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.85|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.85|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.84|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.82|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.8|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.79|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.79|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.78|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.78|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.427|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 112/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|1/28|
|bone|5/26|
|breast|9/33|
|central nervous system|11/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|2/21|
|liver|4/20|
|lung|13/75|
|lymphocyte|0/16|
|ovary|3/26|
|pancreas|6/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8181
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHMP7 Expression in NALM6 Cells: 5.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>