CHRNA10 [The Human Chemical-Genetic Interaction Map Project]

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======= CHRNA10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHRNA10
  * **<color #00a2e8>Official Name</color>**: cholinergic receptor nicotinic alpha 10 subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57053|57053]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZZ6|Q9GZZ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHRNA10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHRNA10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606372|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. {ECO:0000269|PubMed:11752216}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan memb|
|Neur chan LBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cholinergic synapse|
|detection of mechanical stimulus involved in sensory perception of sound|
|acetylcholine-gated cation-selective channel activity|
|integral component of postsynaptic specialization membrane|
|synaptic transmission, cholinergic|
|detection of mechanical stimulus involved in sensory perception|
|detection of mechanical stimulus|
|extracellular ligand-gated ion channel activity|
|calcium channel activity|
|excitatory postsynaptic potential|
|negative regulation of ERK1 and ERK2 cascade|
|chemical synaptic transmission, postsynaptic|
|inner ear morphogenesis|
|regulation of postsynaptic membrane potential|
|ear morphogenesis|
|detection of external stimulus|
|detection of abiotic stimulus|
|perikaryon|
|transmembrane signaling receptor activity|
|sensory perception of sound|
|negative regulation of MAPK cascade|
|sensory perception of mechanical stimulus|
|inner ear development|
|calcium ion transmembrane transport|
|response to mechanical stimulus|
|ear development|
|calcium ion transport|
|sensory organ morphogenesis|
|synapse|
|positive regulation of cytosolic calcium ion concentration|
|embryonic organ morphogenesis|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|axon|
|divalent inorganic cation transport|
|neuron projection|
|regulation of cytosolic calcium ion concentration|
|signaling receptor binding|
|negative regulation of protein phosphorylation|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|embryonic organ development|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|negative regulation of phosphorylation|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|negative regulation of intracellular signal transduction|
|detection of stimulus involved in sensory perception|
|sensory organ development|
|cell junction|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|inorganic cation transmembrane transport|
|embryonic morphogenesis|
|negative regulation of protein modification process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|detection of stimulus|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|cell-cell signaling|
|response to abiotic stimulus|
|negative regulation of signal transduction|
|transmembrane transport|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.89|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.82|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8755
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.5 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHRNA10 Expression in NALM6 Cells: 1.5'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>