CHRNA3 [The Human Chemical-Genetic Interaction Map Project]

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======= CHRNA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHRNA3
  * **<color #00a2e8>Official Name</color>**: cholinergic receptor nicotinic alpha 3 subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1136|1136]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32297|P32297]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHRNA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHRNA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118503|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan memb|
|Neur chan LBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of acetylcholine secretion, neurotransmission|
|synaptic transmission involved in micturition|
|regulation of synaptic transmission, cholinergic|
|micturition|
|behavioral response to nicotine|
|activation of transmembrane receptor protein tyrosine kinase activity|
|ligand-gated ion channel activity|
|acetylcholine-gated cation-selective channel activity|
|acetylcholine receptor activity|
|acetylcholine binding|
|acetylcholine-gated channel complex|
|synaptic transmission, cholinergic|
|acetylcholine receptor signaling pathway|
|plasma membrane raft|
|cellular response to acetylcholine|
|response to acetylcholine|
|neuromuscular synaptic transmission|
|postsynaptic signal transduction|
|excretion|
|extracellular ligand-gated ion channel activity|
|response to nicotine|
|regulation of smooth muscle contraction|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|regulation of dendrite morphogenesis|
|signal transduction involved in cellular response to ammonium ion|
|regulation of amine transport|
|regulation of response to drug|
|regulation of postsynaptic membrane potential|
|regulation of neurotransmitter secretion|
|renal system process|
|cellular response to ammonium ion|
|regulation of neurotransmitter transport|
|adult behavior|
|regulation of dendrite development|
|regulation of muscle contraction|
|response to ammonium ion|
|locomotory behavior|
|postsynaptic membrane|
|regulation of muscle system process|
|postsynaptic density|
|synapse|
|regulation of cell morphogenesis involved in differentiation|
|neuron projection|
|activation of protein kinase activity|
|regulation of neurotransmitter levels|
|neuronal cell body|
|cellular response to drug|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of protein kinase activity|
|cell junction|
|behavior|
|positive regulation of kinase activity|
|regulation of system process|
|cellular response to hormone stimulus|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|regulation of secretion by cell|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of neurogenesis|
|cellular protein-containing complex assembly|
|regulation of kinase activity|
|response to hormone|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|ion transmembrane transport|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|response to drug|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7037
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHRNA3 Expression in NALM6 Cells: 2.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>