CHRNB1 [The Human Chemical-Genetic Interaction Map Project]

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======= CHRNB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHRNB1
  * **<color #00a2e8>Official Name</color>**: cholinergic receptor nicotinic beta 1 subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1140|1140]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11230|P11230]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHRNB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHRNB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/100710|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. {ECO:0000269|PubMed:27375219}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan memb|
|Neur chan LBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|behavioral response to nicotine|
|ligand-gated ion channel activity|
|channel activity|
|acetylcholine receptor activity|
|acetylcholine-gated cation-selective channel activity|
|acetylcholine-gated channel complex|
|acetylcholine binding|
|synaptic transmission, cholinergic|
|integral component of postsynaptic specialization membrane|
|postsynaptic membrane organization|
|skeletal muscle contraction|
|neuromuscular synaptic transmission|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|multicellular organismal movement|
|musculoskeletal movement|
|extracellular ligand-gated ion channel activity|
|response to nicotine|
|muscle fiber development|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|neuromuscular junction|
|postsynapse organization|
|regulation of postsynaptic membrane potential|
|striated muscle contraction|
|striated muscle cell development|
|adult behavior|
|muscle cell development|
|striated muscle cell differentiation|
|muscle cell differentiation|
|muscle contraction|
|synapse|
|synapse organization|
|muscle system process|
|neuron projection|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|synaptic signaling|
|muscle structure development|
|response to toxic substance|
|cell junction|
|behavior|
|cation transport|
|membrane organization|
|ion transmembrane transport|
|response to drug|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|cell development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.76|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.87|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.88|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.93|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7392
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHRNB1 Expression in NALM6 Cells: 3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>