CHRNB3 [The Human Chemical-Genetic Interaction Map Project]

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======= CHRNB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHRNB3
  * **<color #00a2e8>Official Name</color>**: cholinergic receptor nicotinic beta 3 subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1142|1142]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05901|Q05901]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHRNB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHRNB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118508|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan memb|
|Neur chan LBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dopaminergic synapse|
|channel activity|
|acetylcholine-gated cation-selective channel activity|
|acetylcholine receptor activity|
|acetylcholine binding|
|acetylcholine-gated channel complex|
|synaptic transmission, cholinergic|
|neuromuscular synaptic transmission|
|extracellular ligand-gated ion channel activity|
|response to nicotine|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|regulation of synaptic vesicle exocytosis|
|regulation of postsynaptic membrane potential|
|regulation of neurotransmitter secretion|
|protein heterooligomerization|
|regulation of synaptic vesicle cycle|
|regulation of neurotransmitter transport|
|regulation of regulated secretory pathway|
|postsynaptic membrane|
|regulation of exocytosis|
|synapse|
|neuron projection|
|regulation of neurotransmitter levels|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|response to toxic substance|
|protein complex oligomerization|
|cell junction|
|regulation of vesicle-mediated transport|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cellular localization|
|ion transmembrane transport|
|response to drug|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.42|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.12|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.1|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.9|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15825
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHRNB3 Expression in NALM6 Cells: -3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>