CIB1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= CIB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CIB1
  * **<color #00a2e8>Official Name</color>**: calcium and integrin binding 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10519|10519]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99828|Q99828]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CIB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CIB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602293|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin- stimulated megakaryocytes preventing platelet aggregation. Up- regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N- myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of germ cell proliferation|
|positive regulation of male germ cell proliferation|
|endomitotic cell cycle|
|calcium-dependent protein kinase inhibitor activity|
|thrombopoietin-mediated signaling pathway|
|negative regulation of megakaryocyte differentiation|
|regulation of male germ cell proliferation|
|regulation of germ cell proliferation|
|protein serine/threonine kinase inhibitor activity|
|protein membrane anchor|
|Ras GTPase binding|
|positive regulation of calcineurin-NFAT signaling cascade|
|positive regulation of calcineurin-mediated signaling|
|filopodium tip|
|platelet formation|
|positive regulation of cell adhesion mediated by integrin|
|platelet morphogenesis|
|positive regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of microtubule depolymerization|
|regulation of microtubule depolymerization|
|positive regulation of protein targeting to membrane|
|regulation of calcineurin-NFAT signaling cascade|
|regulation of calcineurin-mediated signaling|
|regulation of protein targeting to membrane|
|negative regulation of microtubule polymerization or depolymerization|
|positive regulation of substrate adhesion-dependent cell spreading|
|cell periphery|
|regulation of cell migration involved in sprouting angiogenesis|
|positive regulation of sprouting angiogenesis|
|positive regulation of calcium-mediated signaling|
|regulation of cell adhesion mediated by integrin|
|negative regulation of protein kinase B signaling|
|cellular response to nerve growth factor stimulus|
|response to ischemia|
|positive regulation of cell-matrix adhesion|
|response to nerve growth factor|
|regulation of substrate adhesion-dependent cell spreading|
|cytoplasmic microtubule organization|
|regulation of megakaryocyte differentiation|
|positive regulation of protein localization to plasma membrane|
|positive regulation of blood vessel endothelial cell migration|
|negative regulation of protein depolymerization|
|positive regulation of protein localization to cell periphery|
|regulation of sprouting angiogenesis|
|negative regulation of protein complex disassembly|
|negative regulation of myeloid cell differentiation|
|positive regulation of reproductive process|
|chemokine-mediated signaling pathway|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein targeting|
|regulation of protein depolymerization|
|regulation of blood vessel endothelial cell migration|
|cellular response to chemokine|
|response to chemokine|
|regulation of protein localization to plasma membrane|
|ruffle membrane|
|extrinsic apoptotic signaling pathway|
|regulation of calcium-mediated signaling|
|positive regulation of endothelial cell migration|
|sarcolemma|
|regulation of protein complex disassembly|
|regulation of protein localization to cell periphery|
|regulation of cell-matrix adhesion|
|positive regulation of cell-substrate adhesion|
|positive regulation of protein localization to membrane|
|ion channel binding|
|growth cone|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of hemopoiesis|
|negative regulation of cytoskeleton organization|
|positive regulation of epithelial cell migration|
|vesicle|
|spermatid development|
|positive regulation of NF-kappaB transcription factor activity|
|positive regulation of intracellular protein transport|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|spermatid differentiation|
|regulation of endothelial cell migration|
|regulation of reproductive process|
|positive regulation of angiogenesis|
|positive regulation of cell growth|
|regulation of cell division|
|lamellipodium|
|double-strand break repair|
|negative regulation of cell projection organization|
|positive regulation of vasculature development|
|regulation of microtubule cytoskeleton organization|
|protein C-terminus binding|
|regulation of protein localization to membrane|
|positive regulation of intracellular transport|
|regulation of cell-substrate adhesion|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of epithelial cell migration|
|myeloid cell differentiation|
|regulation of protein kinase B signaling|
|regulation of microtubule-based process|
|negative regulation of protein kinase activity|
|regulation of myeloid cell differentiation|
|negative regulation of neuron differentiation|
|regulation of intracellular protein transport|
|cellular response to tumor necrosis factor|
|negative regulation of kinase activity|
|germ cell development|
|positive regulation of growth|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|negative regulation of transferase activity|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|angiogenesis|
|apical plasma membrane|
|neuron projection|
|regulation of vasculature development|
|positive regulation of cellular protein localization|
|negative regulation of cell development|
|positive regulation of protein serine/threonine kinase activity|
|regulation of supramolecular fiber organization|
|regulation of intracellular transport|
|cellular process involved in reproduction in multicellular organism|
|neuronal cell body|
|negative regulation of organelle organization|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|regulation of cell growth|
|dendrite|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of hemopoiesis|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|microtubule cytoskeleton organization|
|blood vessel development|
|regulation of cell morphogenesis|
|centrosome|
|cell division|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|DNA repair|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|spermatogenesis|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|male gamete generation|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|immune system development|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|microtubule-based process|
|regulation of growth|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|mitotic cell cycle|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|calcium ion binding|
|cell morphogenesis|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|regulation of MAPK cascade|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|apoptotic process|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|Golgi apparatus|
|positive regulation of transport|
|negative regulation of cell death|
|multi-organism reproductive process|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell death|
|response to cytokine|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17940
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CIB1 Expression in NALM6 Cells: 5.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>