CIT [The Human Chemical-Genetic Interaction Map Project]

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======= CIT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CIT
  * **<color #00a2e8>Official Name</color>**: citron rho-interacting serine/threonine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11113|11113]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14578|O14578]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CIT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CIT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605629|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase C|
|Pkinase|
|CNH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi cisterna|
|positive regulation of cytokinesis|
|cortical actin cytoskeleton organization|
|neuron apoptotic process|
|cortical cytoskeleton organization|
|neuron death|
|cleavage furrow|
|scaffold protein binding|
|mitotic cytokinesis|
|peptidyl-threonine phosphorylation|
|positive regulation of cell division|
|PDZ domain binding|
|regulation of cytokinesis|
|peptidyl-threonine modification|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|actomyosin structure organization|
|liver development|
|hepaticobiliary system development|
|G2/M transition of mitotic cell cycle|
|SH3 domain binding|
|Golgi organization|
|cell cycle G2/M phase transition|
|midbody|
|regulation of cell division|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|actin cytoskeleton|
|regulation of actin filament organization|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|positive regulation of cell cycle process|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|protein serine/threonine kinase activity|
|cytoskeleton|
|neuronal cell body|
|regulation of cellular component size|
|positive regulation of cell cycle|
|regulation of actin filament-based process|
|gland development|
|endomembrane system organization|
|cell division|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|actin filament-based process|
|mitotic cell cycle process|
|mitotic cell cycle|
|regulation of cell cycle process|
|peptidyl-amino acid modification|
|apoptotic process|
|protein phosphorylation|
|cell cycle process|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|regulation of cell cycle|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|ATP binding|
|generation of neurons|
|neurogenesis|
|intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.71|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1784
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CIT Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>