CKAP5 [The Human Chemical-Genetic Interaction Map Project]

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======= CKAP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CKAP5
  * **<color #00a2e8>Official Name</color>**: cytoskeleton associated protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9793|9793]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14008|Q14008]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CKAP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CKAP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611142|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch- TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CLASP N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment or maintenance of microtubule cytoskeleton polarity|
|gamma-tubulin complex|
|establishment or maintenance of cytoskeleton polarity|
|microtubule plus-end binding|
|microtubule depolymerization|
|microtubule plus-end|
|centrosome duplication|
|microtubule polymerization|
|protein depolymerization|
|microtubule polymerization or depolymerization|
|centrosome cycle|
|kinetochore|
|protein polymerization|
|condensed chromosome kinetochore|
|microtubule organizing center organization|
|ciliary basal body-plasma membrane docking|
|spindle pole|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|cellular protein complex disassembly|
|microtubule cytoskeleton|
|spindle organization|
|organelle localization by membrane tethering|
|membrane docking|
|nucleic acid transport|
|RNA transport|
|regulation of G2/M transition of mitotic cell cycle|
|establishment of RNA localization|
|establishment or maintenance of cell polarity|
|regulation of cell cycle G2/M phase transition|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex disassembly|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|cadherin binding|
|cilium assembly|
|cilium organization|
|cellular component disassembly|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|supramolecular fiber organization|
|cell projection assembly|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|organelle localization|
|protein-containing complex|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|organelle assembly|
|cellular protein-containing complex assembly|
|nucleolus|
|cell cycle process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|cell cycle|
|protein-containing complex assembly|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.81|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.35|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.34|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.16|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.1|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.98|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.96|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.95|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.83|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.77|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.77|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.72|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.74|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.74|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.75|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.76|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.77|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.78|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.82|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.84|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.86|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.88|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.91|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.91|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.92|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.93|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.96|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.96|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.96|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.98|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.99|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|2|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.04|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.07|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.11|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.12|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.14|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|2.16|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.17|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.17|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.19|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.22|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|2.24|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.24|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|2.24|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.26|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|2.34|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.35|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|2.43|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.44|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|2.49|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|2.51|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.53|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.62|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.62|
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.64|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|2.69|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|2.7|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.82|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|3|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|3.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cdc73|CDC73]]|0.551|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.537|
|[[:human genes:v:vasn|VASN]]|0.508|
|[[:human genes:p:psmb4|PSMB4]]|0.506|
|[[:human genes:c:cwc22|CWC22]]|0.506|
|[[:human genes:t:tfip11|TFIP11]]|0.502|
|[[:human genes:c:cope|COPE]]|0.498|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.494|
|[[:human genes:p:psmd3|PSMD3]]|0.494|
|[[:human genes:c:cdc6|CDC6]]|0.494|
|[[:human genes:r:rps9|RPS9]]|0.49|
|[[:human genes:c:cdca3|CDCA3]]|0.487|
|[[:human genes:n:nup155|NUP155]]|0.484|
|[[:human genes:e:eif4a3|EIF4A3]]|0.482|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.474|
|[[:human genes:t:trim52|TRIM52]]|0.473|
|[[:human genes:c:c14orf93|C14orf93]]|0.471|
|[[:human genes:p:paf1|PAF1]]|0.47|
|[[:human genes:p:psmd1|PSMD1]]|0.47|
|[[:human genes:r:rpl38|RPL38]]|0.467|
|[[:human genes:c:casc5|CASC5]]|0.467|
|[[:human genes:r:rrp15|RRP15]]|0.466|
|[[:human genes:a:aaas|AAAS]]|0.465|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.463|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.463|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.462|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.462|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.461|
|[[:human genes:r:rps28|RPS28]]|0.46|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.46|
|[[:human genes:b:bod1l1|BOD1L1]]|0.459|
|[[:human genes:o:orc1|ORC1]]|0.459|
|[[:human genes:r:rps12|RPS12]]|0.458|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.455|
|[[:human genes:e:egr2|EGR2]]|0.454|
|[[:human genes:c:cep192|CEP192]]|0.451|
|[[:human genes:p:psma6|PSMA6]]|0.45|
|[[:human genes:r:rps3a|RPS3A]]|0.448|
|[[:human genes:r:rbm39|RBM39]]|0.446|
|[[:human genes:c:cnot1|CNOT1]]|0.445|
|[[:human genes:n:ndc1|NDC1]]|0.444|
|[[:human genes:c:ctnnbl1|CTNNBL1]]|0.444|
|[[:human genes:n:narfl|NARFL]]|0.444|
|[[:human genes:r:rpl14|RPL14]]|0.444|
|[[:human genes:p:ppfia4|PPFIA4]]|0.444|
|[[:human genes:s:snrpa1|SNRPA1]]|0.443|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.443|
|[[:human genes:m:mt1e|MT1E]]|0.442|
|[[:human genes:r:rps2|RPS2]]|0.442|
|[[:human genes:p:prim1|PRIM1]]|0.442|
|[[:human genes:p:pds5b|PDS5B]]|0.441|
|[[:human genes:r:rbbp5|RBBP5]]|0.437|
|[[:human genes:s:sf3b2|SF3B2]]|0.437|
|[[:human genes:n:nupl1|NUPL1]]|0.436|
|[[:human genes:s:stil|STIL]]|0.436|
|[[:human genes:p:psmb2|PSMB2]]|0.436|
|[[:human genes:p:psap|PSAP]]|0.435|
|[[:human genes:s:snrnp70|SNRNP70]]|0.434|
|[[:human genes:r:riok2|RIOK2]]|0.434|
|[[:human genes:p:psma7|PSMA7]]|0.432|
|[[:human genes:r:rps5|RPS5]]|0.432|
|[[:human genes:n:nup160|NUP160]]|0.431|
|[[:human genes:c:ctr9|CTR9]]|0.428|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.427|
|[[:human genes:f:fam20a|FAM20A]]|0.427|
|[[:human genes:o:orc6|ORC6]]|0.427|
|[[:human genes:s:sf3a1|SF3A1]]|0.426|
|[[:human genes:p:ppie|PPIE]]|0.426|
|[[:human genes:p:prmt8|PRMT8]]|0.425|
|[[:human genes:s:s1pr4|S1PR4]]|0.425|
|[[:human genes:s:sf3a3|SF3A3]]|0.423|
|[[:human genes:p:psmd6|PSMD6]]|0.422|
|[[:human genes:p:plk4|PLK4]]|0.422|
|[[:human genes:z:zfand5|ZFAND5]]|0.421|
|[[:human genes:r:rplp2|RPLP2]]|0.421|
|[[:human genes:p:psmc6|PSMC6]]|0.421|
|[[:human genes:l:lrr1|LRR1]]|0.42|
|[[:human genes:p:pole|POLE]]|0.42|
|[[:human genes:z:znf106|ZNF106]]|0.417|
|[[:human genes:t:tceb3c|TCEB3C]]|0.417|
|[[:human genes:m:mybl2|MYBL2]]|0.416|
|[[:human genes:i:ints5|INTS5]]|0.415|
|[[:human genes:p:pola2|POLA2]]|0.414|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.414|
|[[:human genes:l:lad1|LAD1]]|0.412|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.411|
|[[:human genes:e:exosc3|EXOSC3]]|0.41|
|[[:human genes:c:chd4|CHD4]]|0.409|
|[[:human genes:k:kctd17|KCTD17]]|0.409|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.408|
|[[:human genes:d:ddtl|DDTL]]|0.408|
|[[:human genes:p:psmc1|PSMC1]]|0.408|
|[[:human genes:m:mdm2|MDM2]]|0.408|
|[[:human genes:p:prpf3|PRPF3]]|0.407|
|[[:human genes:c:ccdc94|CCDC94]]|0.407|
|[[:human genes:g:gar1|GAR1]]|0.407|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.406|
|[[:human genes:s:supt6h|SUPT6H]]|0.404|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.404|
|[[:human genes:a:adrm1|ADRM1]]|0.403|
|[[:human genes:c:cgb2|CGB2]]|0.403|
|[[:human genes:a:acsf2|ACSF2]]|0.401|
|[[:human genes:c:cltc|CLTC]]|0.4|
|[[:human genes:n:nup205|NUP205]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 698/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|28/28|
|bone|25/26|
|breast|31/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|18/21|
|liver|19/20|
|lung|73/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|26/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 390
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CKAP5 Expression in NALM6 Cells: 8.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>