CLASP2 [The Human Chemical-Genetic Interaction Map Project]

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======= CLASP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLASP2
  * **<color #00a2e8>Official Name</color>**: cytoplasmic linker associated protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23122|23122]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75122|O75122]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLASP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLASP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605853|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CLASP N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of wound healing, spreading of epidermal cells|
|positive regulation of basement membrane assembly involved in embryonic body morphogenesis|
|regulation of basement membrane organization|
|basal cortex|
|regulation of basement membrane assembly involved in embryonic body morphogenesis|
|regulation of wound healing, spreading of epidermal cells|
|kinetochore microtubule|
|positive regulation of extracellular matrix disassembly|
|dystroglycan binding|
|exit from mitosis|
|regulation of extracellular matrix disassembly|
|negative regulation of morphogenesis of an epithelium|
|microtubule plus-end binding|
|negative regulation of focal adhesion assembly|
|microtubule nucleation|
|positive regulation of extracellular matrix organization|
|negative regulation of stress fiber assembly|
|negative regulation of adherens junction organization|
|negative regulation of cell junction assembly|
|negative regulation of actin filament bundle assembly|
|negative regulation of microtubule depolymerization|
|microtubule anchoring|
|regulation of microtubule depolymerization|
|microtubule polymerization|
|regulation of gastrulation|
|negative regulation of microtubule polymerization or depolymerization|
|positive regulation of embryonic development|
|negative regulation of cell-matrix adhesion|
|regulation of extracellular matrix organization|
|cell leading edge|
|microtubule polymerization or depolymerization|
|cytoplasmic microtubule|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|negative regulation of protein depolymerization|
|negative regulation of cell-substrate adhesion|
|regulation of adherens junction organization|
|negative regulation of protein complex disassembly|
|negative regulation of wound healing|
|mitotic spindle organization|
|mitotic spindle|
|regulation of stress fiber assembly|
|regulation of microtubule polymerization or depolymerization|
|regulation of epithelial to mesenchymal transition|
|regulation of protein depolymerization|
|kinetochore|
|negative regulation of response to wounding|
|protein polymerization|
|positive regulation of exocytosis|
|regulation of actomyosin structure organization|
|condensed chromosome kinetochore|
|regulation of cell junction assembly|
|vesicle targeting|
|regulation of actin filament bundle assembly|
|microtubule organizing center organization|
|ruffle membrane|
|microtubule cytoskeleton organization involved in mitosis|
|regulation of protein complex disassembly|
|regulation of cell-matrix adhesion|
|regulation of embryonic development|
|negative regulation of supramolecular fiber organization|
|Golgi organization|
|cell cortex|
|regulation of wound healing|
|negative regulation of cytoskeleton organization|
|positive regulation of epithelial cell migration|
|mitotic nuclear division|
|spindle organization|
|microtubule organizing center|
|regulation of response to wounding|
|trans-Golgi network|
|establishment of vesicle localization|
|regulation of morphogenesis of an epithelium|
|protein localization to plasma membrane|
|vesicle localization|
|regulation of microtubule cytoskeleton organization|
|establishment or maintenance of cell polarity|
|regulation of cell-substrate adhesion|
|regulation of epithelial cell migration|
|regulation of microtubule-based process|
|regulation of exocytosis|
|protein localization to cell periphery|
|microtubule binding|
|negative regulation of cell migration|
|regulation of actin filament organization|
|mitotic cell cycle phase transition|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|cell cycle phase transition|
|nuclear division|
|negative regulation of cellular component movement|
|organelle fission|
|microtubule|
|negative regulation of locomotion|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|establishment of organelle localization|
|negative regulation of response to external stimulus|
|negative regulation of organelle organization|
|regulation of actin filament-based process|
|positive regulation of secretion by cell|
|focal adhesion|
|endomembrane system organization|
|positive regulation of secretion|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|protein localization to membrane|
|cell division|
|positive regulation of cell migration|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|organelle localization|
|mitotic cell cycle process|
|microtubule-based process|
|regulation of cell adhesion|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|regulation of secretion by cell|
|regulation of secretion|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|regulation of cell motility|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|Golgi apparatus|
|positive regulation of transport|
|regulation of cellular component movement|
|cell cycle process|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|regulation of response to stress|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.95|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.75|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.8|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.29|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.78|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|4.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kif4a|KIF4A]]|0.437|
|[[:human genes:p:ppp2r1a|PPP2R1A]]|0.425|
|[[:human genes:k:kif18b|KIF18B]]|0.414|
|[[:human genes:k:kif2c|KIF2C]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16263
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLASP2 Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>