CLDN1 [The Human Chemical-Genetic Interaction Map Project]

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======= CLDN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLDN1
  * **<color #00a2e8>Official Name</color>**: claudin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9076|9076]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95832|O95832]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLDN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLDN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603718|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). {ECO:0000269|PubMed:23407391}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PMP22 Claudin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|xenobiotic transport across blood-nerve barrier|
|cellular response to butyrate|
|response to butyrate|
|establishment of blood-nerve barrier|
|positive regulation of bicellular tight junction assembly|
|cellular response to lead ion|
|hyperosmotic salinity response|
|response to interleukin-18|
|establishment of endothelial intestinal barrier|
|xenobiotic transport|
|regulation of bicellular tight junction assembly|
|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|
|response to salt stress|
|establishment of skin barrier|
|response to lead ion|
|hyperosmotic response|
|regulation of water loss via skin|
|liver regeneration|
|establishment of endothelial barrier|
|positive regulation of cell junction assembly|
|bicellular tight junction assembly|
|tight junction assembly|
|tight junction organization|
|response to dexamethasone|
|apical junction assembly|
|endothelial cell development|
|cellular response to fatty acid|
|lateral plasma membrane|
|multicellular organismal water homeostasis|
|water homeostasis|
|peripheral nervous system development|
|animal organ regeneration|
|virus receptor activity|
|response to osmotic stress|
|endothelial cell differentiation|
|response to fatty acid|
|regulation of cell junction assembly|
|response to antineoplastic agent|
|viral entry into host cell|
|endothelium development|
|entry into host|
|entry into host cell|
|cell-cell junction assembly|
|protein heterooligomerization|
|bicellular tight junction|
|liver development|
|response to ethanol|
|hepaticobiliary system development|
|cell-cell junction organization|
|response to glucocorticoid|
|cellular response to transforming growth factor beta stimulus|
|interaction with host|
|regeneration|
|response to corticosteroid|
|response to transforming growth factor beta|
|cellular response to interferon-gamma|
|cell junction assembly|
|response to interferon-gamma|
|structural molecule activity|
|cellular response to metal ion|
|epithelial cell development|
|response to ketone|
|basolateral plasma membrane|
|viral life cycle|
|cellular response to acid chemical|
|cell junction organization|
|cellular response to inorganic substance|
|response to alcohol|
|cellular response to tumor necrosis factor|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|response to tumor necrosis factor|
|aging|
|response to xenobiotic stimulus|
|response to antibiotic|
|response to lipopolysaccharide|
|apical plasma membrane|
|multicellular organismal homeostasis|
|response to molecule of bacterial origin|
|response to steroid hormone|
|protein homooligomerization|
|response to acid chemical|
|response to metal ion|
|skin development|
|gland development|
|regulation of body fluid levels|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|response to toxic substance|
|protein complex oligomerization|
|cellular response to lipid|
|positive regulation of cellular component biogenesis|
|response to growth factor|
|response to inorganic substance|
|protein-containing complex|
|epithelial cell differentiation|
|response to bacterium|
|viral process|
|innate immune response|
|symbiotic process|
|interspecies interaction between organisms|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cellular response to cytokine stimulus|
|response to drug|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to cytokine|
|chemical homeostasis|
|epithelium development|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|cell development|
|tissue development|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13580
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLDN1 Expression in NALM6 Cells: -3.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>