CLN6 [The Human Chemical-Genetic Interaction Map Project]

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======= CLN6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLN6
  * **<color #00a2e8>Official Name</color>**: CLN6 transmembrane ER protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54982|54982]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NWW5|Q9NWW5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLN6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLN6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606725|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|locomotion involved in locomotory behavior|
|lysosomal lumen acidification|
|regulation of lysosomal lumen pH|
|ganglioside metabolic process|
|vacuolar acidification|
|intracellular pH reduction|
|pH reduction|
|lysosome organization|
|lytic vacuole organization|
|glycosphingolipid metabolic process|
|ceramide metabolic process|
|regulation of intracellular pH|
|regulation of cellular pH|
|regulation of pH|
|glycolipid metabolic process|
|cellular monovalent inorganic cation homeostasis|
|liposaccharide metabolic process|
|cholesterol metabolic process|
|secondary alcohol metabolic process|
|vacuole organization|
|sterol metabolic process|
|monovalent inorganic cation homeostasis|
|sphingolipid metabolic process|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|locomotory behavior|
|membrane lipid metabolic process|
|visual perception|
|sensory perception of light stimulus|
|steroid metabolic process|
|endoplasmic reticulum lumen|
|alcohol metabolic process|
|positive regulation of proteolysis|
|organic hydroxy compound metabolic process|
|behavior|
|cellular cation homeostasis|
|cellular ion homeostasis|
|protein catabolic process|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of proteolysis|
|cellular chemical homeostasis|
|cellular amide metabolic process|
|ion homeostasis|
|protein homodimerization activity|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|sensory perception|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chemical homeostasis|
|lipid metabolic process|
|locomotion|
|nervous system process|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.1|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.9|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|3.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.551|
|[[:human genes:c:chd4|CHD4]]|0.531|
|[[:human genes:t:tceb3c|TCEB3C]]|0.516|
|[[:human genes:r:rpl6|RPL6]]|0.513|
|[[:human genes:c:ccna2|CCNA2]]|0.502|
|[[:human genes:o:orc1|ORC1]]|0.499|
|[[:human genes:p:polr2j3|POLR2J3]]|0.49|
|[[:human genes:o:orc6|ORC6]]|0.49|
|[[:human genes:s:snrnp70|SNRNP70]]|0.489|
|[[:human genes:d:dtl|DTL]]|0.486|
|[[:human genes:p:polr1a|POLR1A]]|0.481|
|[[:human genes:p:psmb2|PSMB2]]|0.477|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.476|
|[[:human genes:c:copb1|COPB1]]|0.475|
|[[:human genes:a:aamp|AAMP]]|0.475|
|[[:human genes:i:ik|IK]]|0.466|
|[[:human genes:v:vasn|VASN]]|0.464|
|[[:human genes:p:polr2a|POLR2A]]|0.463|
|[[:human genes:s:snip1|SNIP1]]|0.457|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.452|
|[[:human genes:a:aqr|AQR]]|0.452|
|[[:human genes:s:supt5h|SUPT5H]]|0.452|
|[[:human genes:r:rpl35|RPL35]]|0.451|
|[[:human genes:c:cdh24|CDH24]]|0.449|
|[[:human genes:s:sf3a3|SF3A3]]|0.448|
|[[:human genes:n:nol10|NOL10]]|0.445|
|[[:human genes:c:cep192|CEP192]]|0.445|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.445|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.445|
|[[:human genes:n:nxf1|NXF1]]|0.445|
|[[:human genes:p:psma6|PSMA6]]|0.444|
|[[:human genes:r:rpl30|RPL30]]|0.444|
|[[:human genes:r:rps12|RPS12]]|0.444|
|[[:human genes:m:mms22l|MMS22L]]|0.444|
|[[:human genes:t:timeless|TIMELESS]]|0.443|
|[[:human genes:c:cactin|CACTIN]]|0.442|
|[[:human genes:a:akirin2|AKIRIN2]]|0.442|
|[[:human genes:p:psmc6|PSMC6]]|0.442|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.442|
|[[:human genes:c:crnkl1|CRNKL1]]|0.44|
|[[:human genes:c:cdca3|CDCA3]]|0.44|
|[[:human genes:m:mfsd12|MFSD12]]|0.44|
|[[:human genes:t:tuba8|TUBA8]]|0.438|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.437|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.436|
|[[:human genes:n:npipb5|NPIPB5]]|0.436|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.436|
|[[:human genes:p:plekha4|PLEKHA4]]|0.436|
|[[:human genes:m:madcam1|MADCAM1]]|0.435|
|[[:human genes:r:rplp1|RPLP1]]|0.433|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.433|
|[[:human genes:p:psmb4|PSMB4]]|0.432|
|[[:human genes:s:snx15|SNX15]]|0.431|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.431|
|[[:human genes:s:sec13|SEC13]]|0.43|
|[[:human genes:o:osbp|OSBP]]|0.43|
|[[:human genes:r:rrp7a|RRP7A]]|0.429|
|[[:human genes:t:ticrr|TICRR]]|0.429|
|[[:human genes:d:dock6|DOCK6]]|0.428|
|[[:human genes:g:golga6b|GOLGA6B]]|0.428|
|[[:human genes:m:mylk3|MYLK3]]|0.427|
|[[:human genes:l:lrr1|LRR1]]|0.427|
|[[:human genes:s:slc4a1|SLC4A1]]|0.426|
|[[:human genes:d:ddtl|DDTL]]|0.426|
|[[:human genes:e:exosc9|EXOSC9]]|0.426|
|[[:human genes:t:tfip11|TFIP11]]|0.424|
|[[:human genes:p:plk1|PLK1]]|0.424|
|[[:human genes:c:ccdc116|CCDC116]]|0.424|
|[[:human genes:g:gpx4|GPX4]]|0.424|
|[[:human genes:u:utp3|UTP3]]|0.423|
|[[:human genes:x:xylt2|XYLT2]]|0.423|
|[[:human genes:i:itga2b|ITGA2B]]|0.423|
|[[:human genes:p:psmd14|PSMD14]]|0.422|
|[[:human genes:c:cacna1a|CACNA1A]]|0.422|
|[[:human genes:p:psmc5|PSMC5]]|0.421|
|[[:human genes:p:prpf3|PRPF3]]|0.42|
|[[:human genes:e:eif4a3|EIF4A3]]|0.42|
|[[:human genes:p:paf1|PAF1]]|0.418|
|[[:human genes:e:eif3g|EIF3G]]|0.418|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.417|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.417|
|[[:human genes:g:gramd1a|GRAMD1A]]|0.415|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.415|
|[[:human genes:h:hivep3|HIVEP3]]|0.414|
|[[:human genes:c:copg1|COPG1]]|0.414|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.414|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.413|
|[[:human genes:n:nup153|NUP153]]|0.413|
|[[:human genes:c:copa|COPA]]|0.412|
|[[:human genes:m:mt1e|MT1E]]|0.412|
|[[:human genes:p:pan3|PAN3]]|0.412|
|[[:human genes:r:rps2|RPS2]]|0.411|
|[[:human genes:p:psmd3|PSMD3]]|0.411|
|[[:human genes:p:polr2d|POLR2D]]|0.41|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.409|
|[[:human genes:d:ddt|DDT]]|0.408|
|[[:human genes:c:cope|COPE]]|0.408|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.405|
|[[:human genes:s:slc6a17|SLC6A17]]|0.405|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.404|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.404|
|[[:human genes:a:acsf2|ACSF2]]|0.404|
|[[:human genes:c:col2a1|COL2A1]]|0.404|
|[[:human genes:r:rpl14|RPL14]]|0.403|
|[[:human genes:s:sap30bp|SAP30BP]]|0.403|
|[[:human genes:a:aatf|AATF]]|0.403|
|[[:human genes:g:golga6a|GOLGA6A]]|0.402|
|[[:human genes:z:znf541|ZNF541]]|0.402|
|[[:human genes:s:syt9|SYT9]]|0.401|
|[[:human genes:s:supt6h|SUPT6H]]|0.401|
|[[:human genes:n:nupl1|NUPL1]]|0.401|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.4|
|[[:human genes:r:rps10|RPS10]]|0.4|
|[[:human genes:s:smg7|SMG7]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2170
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLN6 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>