CLPP [The Human Chemical-Genetic Interaction Map Project]

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======= CLPP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLPP
  * **<color #00a2e8>Official Name</color>**: caseinolytic mitochondrial matrix peptidase proteolytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8192|8192]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16740|Q16740]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLPP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLPP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601119|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. {ECO:0000269|PubMed:11923310, ECO:0000269|PubMed:15522782}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CLP protease|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endopeptidase Clp complex|
|ATP-dependent peptidase activity|
|protein quality control for misfolded or incompletely synthesized proteins|
|ATPase binding|
|peptidase activity|
|serine-type endopeptidase activity|
|protein homooligomerization|
|mitochondrial matrix|
|protein complex oligomerization|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|mitochondrion|
|proteolysis|
|protein-containing complex assembly|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.74|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.75|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.75|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.8|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.83|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.84|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.88|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.95|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.01|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.05|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.06|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.08|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.08|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.09|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.13|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.23|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.27|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.33|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.35|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.41|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.42|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.47|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.61|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.63|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.78|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.9|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.29|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|6.19|
|[[:results:exp532|TIC10 10μM R08 exp532]]|6.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mipep|MIPEP]]|0.568|
|[[:human genes:n:nars2|NARS2]]|0.535|
|[[:human genes:f:fastkd2|FASTKD2]]|0.523|
|[[:human genes:m:mrpl21|MRPL21]]|0.521|
|[[:human genes:m:mrpl45|MRPL45]]|0.52|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.517|
|[[:human genes:p:pet117|PET117]]|0.516|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.503|
|[[:human genes:l:lars2|LARS2]]|0.497|
|[[:human genes:p:pet112|PET112]]|0.496|
|[[:human genes:d:ddx28|DDX28]]|0.496|
|[[:human genes:e:ears2|EARS2]]|0.49|
|[[:human genes:c:c12orf65|C12orf65]]|0.489|
|[[:human genes:a:acad9|ACAD9]]|0.487|
|[[:human genes:t:trub2|TRUB2]]|0.485|
|[[:human genes:n:ndufa2|NDUFA2]]|0.482|
|[[:human genes:m:mettl17|METTL17]]|0.48|
|[[:human genes:f:ftsj2|FTSJ2]]|0.479|
|[[:human genes:m:mrps25|MRPS25]]|0.479|
|[[:human genes:n:ndufc2|NDUFC2]]|0.475|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.474|
|[[:human genes:n:ndufs2|NDUFS2]]|0.466|
|[[:human genes:n:nubpl|NUBPL]]|0.466|
|[[:human genes:m:mrps6|MRPS6]]|0.463|
|[[:human genes:r:rpusd3|RPUSD3]]|0.46|
|[[:human genes:m:mrps21|MRPS21]]|0.46|
|[[:human genes:n:ndufa1|NDUFA1]]|0.46|
|[[:human genes:p:pnpt1|PNPT1]]|0.458|
|[[:human genes:n:ndufa3|NDUFA3]]|0.458|
|[[:human genes:m:mto1|MTO1]]|0.457|
|[[:human genes:m:mtif2|MTIF2]]|0.457|
|[[:human genes:w:wbscr16|WBSCR16]]|0.457|
|[[:human genes:m:mrpl44|MRPL44]]|0.455|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.454|
|[[:human genes:m:mrp63|MRP63]]|0.454|
|[[:human genes:r:rars2|RARS2]]|0.453|
|[[:human genes:n:ndufa11|NDUFA11]]|0.453|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.452|
|[[:human genes:c:coa3|COA3]]|0.452|
|[[:human genes:m:mrpl23|MRPL23]]|0.452|
|[[:human genes:g:grsf1|GRSF1]]|0.451|
|[[:human genes:m:mterfd1|MTERFD1]]|0.45|
|[[:human genes:m:mrpl3|MRPL3]]|0.449|
|[[:human genes:q:qrsl1|QRSL1]]|0.446|
|[[:human genes:f:fastkd5|FASTKD5]]|0.446|
|[[:human genes:m:mrpl20|MRPL20]]|0.445|
|[[:human genes:n:ndufc1|NDUFC1]]|0.445|
|[[:human genes:m:mrps12|MRPS12]]|0.442|
|[[:human genes:c:chchd1|CHCHD1]]|0.442|
|[[:human genes:g:gfm1|GFM1]]|0.441|
|[[:human genes:m:mrpl47|MRPL47]]|0.438|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.438|
|[[:human genes:c:cox20|COX20]]|0.438|
|[[:human genes:r:rbfa|RBFA]]|0.438|
|[[:human genes:p:prepl|PREPL]]|0.43|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.428|
|[[:human genes:n:ndufb8|NDUFB8]]|0.428|
|[[:human genes:n:ndufa8|NDUFA8]]|0.425|
|[[:human genes:n:ndufv1|NDUFV1]]|0.424|
|[[:human genes:m:mrps26|MRPS26]]|0.424|
|[[:human genes:i:ict1|ICT1]]|0.424|
|[[:human genes:s:selrc1|SELRC1]]|0.423|
|[[:human genes:m:mrps34|MRPS34]]|0.422|
|[[:human genes:m:mrpl1|MRPL1]]|0.422|
|[[:human genes:g:gfm2|GFM2]]|0.421|
|[[:human genes:t:tfb1m|TFB1M]]|0.42|
|[[:human genes:c:cars2|CARS2]]|0.42|
|[[:human genes:d:dap3|DAP3]]|0.419|
|[[:human genes:n:noa1|NOA1]]|0.417|
|[[:human genes:n:ndufb4|NDUFB4]]|0.417|
|[[:human genes:d:dars2|DARS2]]|0.417|
|[[:human genes:m:mrps27|MRPS27]]|0.416|
|[[:human genes:n:ndufb6|NDUFB6]]|0.415|
|[[:human genes:n:ndufb11|NDUFB11]]|0.415|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.415|
|[[:human genes:m:mrps28|MRPS28]]|0.412|
|[[:human genes:w:wars2|WARS2]]|0.412|
|[[:human genes:c:cox15|COX15]]|0.412|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.412|
|[[:human genes:s:ssbp1|SSBP1]]|0.411|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.41|
|[[:human genes:e:eral1|ERAL1]]|0.409|
|[[:human genes:n:ndufs5|NDUFS5]]|0.409|
|[[:human genes:y:yars2|YARS2]]|0.408|
|[[:human genes:c:cox16|COX16]]|0.406|
|[[:human genes:r:rmnd1|RMND1]]|0.406|
|[[:human genes:m:mrpl18|MRPL18]]|0.405|
|[[:human genes:m:mtg1|MTG1]]|0.405|
|[[:human genes:m:mtrf1|MTRF1]]|0.403|
|[[:human genes:a:aars2|AARS2]]|0.403|
|[[:human genes:s:slc31a1|SLC31A1]]|0.403|
|[[:human genes:p:ptcd3|PTCD3]]|0.401|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.401|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.401|
|[[:human genes:m:mrps5|MRPS5]]|0.401|
|[[:human genes:c:coa6|COA6]]|0.4|
|[[:human genes:m:mrps35|MRPS35]]|0.4|
|[[:human genes:s:slc30a9|SLC30A9]]|0.4|
|[[:human genes:m:mrps18a|MRPS18A]]|0.4|
|[[:human genes:t:tefm|TEFM]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 81
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLPP Expression in NALM6 Cells: 5.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>