CLSTN1 [The Human Chemical-Genetic Interaction Map Project]

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======= CLSTN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLSTN1
  * **<color #00a2e8>Official Name</color>**: calsyntenin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22883|22883]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94985|O94985]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLSTN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLSTN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611321|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals (By similarity). {ECO:0000250, ECO:0000269|PubMed:12972431}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integral component of spine apparatus membrane|
|X11-like protein binding|
|postsynaptic endosome|
|regulation of synapse maturation|
|neurotransmitter receptor transport to plasma membrane|
|neurotransmitter receptor transport to postsynaptic membrane|
|establishment of protein localization to postsynaptic membrane|
|protein localization to postsynaptic membrane|
|neurotransmitter receptor transport|
|receptor localization to synapse|
|kinesin binding|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|integral component of postsynaptic density membrane|
|protein localization to synapse|
|positive regulation of synapse assembly|
|GABA-ergic synapse|
|amyloid-beta binding|
|vesicle-mediated transport to the plasma membrane|
|regulation of synapse assembly|
|vesicle-mediated transport in synapse|
|positive regulation of synaptic transmission|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|postsynaptic membrane|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|protein localization to cell periphery|
|protein-containing complex localization|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|establishment of protein localization to membrane|
|glutamatergic synapse|
|regulation of cell growth|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|protein localization to membrane|
|cell-cell adhesion|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|cell junction|
|cell surface|
|Golgi membrane|
|regulation of growth|
|calcium ion binding|
|regulation of nervous system development|
|cell adhesion|
|biological adhesion|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|protein transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.75|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5900
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLSTN1 Expression in NALM6 Cells: 8.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>