CLTA [The Human Chemical-Genetic Interaction Map Project]

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======= CLTA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLTA
  * **<color #00a2e8>Official Name</color>**: clathrin light chain A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1211|1211]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09496|P09496]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLTA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLTA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118960|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge (PubMed:15858577, PubMed:21297582). {ECO:0000305|PubMed:15858577, ECO:0000305|PubMed:21297582}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Clathrin lg ch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|postsynaptic endocytic zone cytoplasmic component|
|clathrin vesicle coat|
|clathrin coat|
|presynaptic endocytic zone membrane|
|clathrin coat of coated pit|
|clathrin coat of trans-Golgi network vesicle|
|clathrin complex|
|clathrin heavy chain binding|
|low-density lipoprotein particle receptor catabolic process|
|low-density lipoprotein receptor particle metabolic process|
|endolysosome membrane|
|clathrin coat assembly|
|low-density lipoprotein particle clearance|
|clathrin-coated endocytic vesicle|
|clathrin-dependent endocytosis|
|receptor catabolic process|
|GTPase binding|
|plasma lipoprotein particle clearance|
|peptide binding|
|synaptic vesicle membrane|
|regulation of plasma lipoprotein particle levels|
|trans-Golgi network membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|receptor metabolic process|
|spindle|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|structural molecule activity|
|antigen processing and presentation|
|receptor-mediated endocytosis|
|cytoplasmic vesicle|
|protein-containing complex binding|
|cell division|
|endocytosis|
|cellular protein catabolic process|
|import into cell|
|protein catabolic process|
|molecular function|
|cellular protein-containing complex assembly|
|membrane organization|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell cycle|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.08|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.94|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17647
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLTA Expression in NALM6 Cells: 6.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>