CLUH [The Human Chemical-Genetic Interaction Map Project]

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======= CLUH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLUH
  * **<color #00a2e8>Official Name</color>**: clustered mitochondria homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23277|23277]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75153|O75153]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLUH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLUH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616184|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear- encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. {ECO:0000255|HAMAP-Rule:MF_03013, ECO:0000269|PubMed:25349259}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|eIF3 p135|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular distribution of mitochondria|
|mitochondrion distribution|
|mitochondrion localization|
|mRNA binding|
|mitochondrion organization|
|organelle localization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-3.23|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.57|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.71|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.78|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.8|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.8|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.95|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.98|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.04|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.12|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.15|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.35|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.49|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.85|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|5.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:oma1|OMA1]]|0.524|
|[[:human genes:c:clpx|CLPX]]|0.464|
|[[:human genes:a:acad9|ACAD9]]|0.458|
|[[:human genes:p:pet117|PET117]]|0.449|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.441|
|[[:human genes:n:nubpl|NUBPL]]|0.429|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.418|
|[[:human genes:g:grsf1|GRSF1]]|0.415|
|[[:human genes:n:nsun4|NSUN4]]|0.414|
|[[:human genes:e:eral1|ERAL1]]|0.412|
|[[:human genes:p:prepl|PREPL]]|0.411|
|[[:human genes:n:ndufs2|NDUFS2]]|0.41|
|[[:human genes:c:cox8a|COX8A]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 228
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLUH Expression in NALM6 Cells: 8.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>