CMA1 [The Human Chemical-Genetic Interaction Map Project]

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======= CMA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CMA1
  * **<color #00a2e8>Official Name</color>**: chymase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1215|1215]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23946|P23946]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CMA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CMA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118938|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Trypsin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-1 beta biosynthetic process|
|interleukin-1 biosynthetic process|
|basement membrane disassembly|
|regulation of angiotensin levels in blood|
|angiotensin maturation|
|cytokine biosynthetic process|
|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|
|interleukin-1 beta production|
|cytokine metabolic process|
|interleukin-1 production|
|basement membrane organization|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|peptide hormone processing|
|regulation of systemic arterial blood pressure by hormone|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|peptide binding|
|serine-type peptidase activity|
|extracellular matrix disassembly|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|cellular response to carbohydrate stimulus|
|midbrain development|
|secretory granule|
|cellular glucose homeostasis|
|regulation of systemic arterial blood pressure|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|cytokine production|
|protein processing|
|positive regulation of angiogenesis|
|serine-type endopeptidase activity|
|response to carbohydrate|
|regulation of blood pressure|
|positive regulation of vasculature development|
|glucose homeostasis|
|carbohydrate homeostasis|
|hormone metabolic process|
|protein maturation|
|regulation of angiogenesis|
|regulation of vasculature development|
|regulation of inflammatory response|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|blood circulation|
|circulatory system process|
|cellular component disassembly|
|peptide metabolic process|
|regulation of hormone levels|
|brain development|
|cellular chemical homeostasis|
|regulation of defense response|
|head development|
|cellular amide metabolic process|
|cellular homeostasis|
|central nervous system development|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|chemical homeostasis|
|proteolysis|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|response to oxygen-containing compound|
|extracellular space|
|homeostatic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|extracellular region|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.565|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14508
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CMA1 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>