CMTR1 [The Human Chemical-Genetic Interaction Map Project]

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======= CMTR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CMTR1
  * **<color #00a2e8>Official Name</color>**: cap methyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23070|23070]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N1G2|Q8N1G2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CMTR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CMTR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616189|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FtsJ|
|G-patch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cap mRNA methylation|
|mRNA (nucleoside-2-O-)-methyltransferase activity|
|cap1 mRNA methylation|
|mRNA methylation|
|mRNA modification|
|7-methylguanosine mRNA capping|
|7-methylguanosine RNA capping|
|RNA capping|
|RNA methylation|
|RNA modification|
|nucleic acid binding|
|macromolecule methylation|
|methylation|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-2.34|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.92|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.76|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.02|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.04|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.11|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.17|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rptor|RPTOR]]|0.523|
|[[:human genes:r:rtcb|RTCB]]|0.507|
|[[:human genes:t:thg1l|THG1L]]|0.496|
|[[:human genes:h:hars|HARS]]|0.494|
|[[:human genes:d:dohh|DOHH]]|0.485|
|[[:human genes:r:rnmt|RNMT]]|0.477|
|[[:human genes:p:pfn1|PFN1]]|0.465|
|[[:human genes:t:trim28|TRIM28]]|0.463|
|[[:human genes:n:nsd1|NSD1]]|0.46|
|[[:human genes:a:alg1|ALG1]]|0.456|
|[[:human genes:s:srp72|SRP72]]|0.456|
|[[:human genes:s:shoc2|SHOC2]]|0.453|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.444|
|[[:human genes:p:pknox1|PKNOX1]]|0.444|
|[[:human genes:s:srp14|SRP14]]|0.439|
|[[:human genes:o:osgep|OSGEP]]|0.437|
|[[:human genes:e:eno1|ENO1]]|0.435|
|[[:human genes:t:tti2|TTI2]]|0.434|
|[[:human genes:m:mtor|MTOR]]|0.431|
|[[:human genes:d:dpagt1|DPAGT1]]|0.429|
|[[:human genes:m:metap2|METAP2]]|0.427|
|[[:human genes:p:pdap1|PDAP1]]|0.424|
|[[:human genes:b:bap1|BAP1]]|0.42|
|[[:human genes:u:uap1|UAP1]]|0.417|
|[[:human genes:g:gfpt1|GFPT1]]|0.411|
|[[:human genes:u:ube2g2|UBE2G2]]|0.411|
|[[:human genes:e:eif4e|EIF4E]]|0.409|
|[[:human genes:w:wdr92|WDR92]]|0.407|
|[[:human genes:o:otud5|OTUD5]]|0.401|
|[[:human genes:c:cbfb|CBFB]]|0.401|
|[[:human genes:t:tprkb|TPRKB]]|0.4|
|[[:human genes:u:ubr5|UBR5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 445/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|18/28|
|blood|15/28|
|bone|16/26|
|breast|14/33|
|central nervous system|42/56|
|cervix|0/4|
|colorectal|7/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|11/21|
|liver|13/20|
|lung|45/75|
|lymphocyte|8/16|
|ovary|19/26|
|pancreas|22/24|
|peripheral nervous system|9/16|
|plasma cell|7/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|19/22|
|urinary tract|19/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 682
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CMTR1 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>