CMYA5 [The Human Chemical-Genetic Interaction Map Project]

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======= CMYA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CMYA5
  * **<color #00a2e8>Official Name</color>**: cardiomyopathy associated 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=202333|202333]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N3K9|Q8N3K9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CMYA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CMYA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612193|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPRY|
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|M band|
|sarcoplasmic reticulum|
|perinuclear region of cytoplasm|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.48|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.27|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.84|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.72|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.95|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.97|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.97|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.99|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.1|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.19|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.31|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|2.31|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.499|
|[[:human genes:v:vasn|VASN]]|0.496|
|[[:human genes:a:aqr|AQR]]|0.493|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.491|
|[[:human genes:c:cope|COPE]]|0.487|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.486|
|[[:human genes:c:ccna2|CCNA2]]|0.483|
|[[:human genes:t:tceb3c|TCEB3C]]|0.483|
|[[:human genes:r:rps2|RPS2]]|0.48|
|[[:human genes:t:tfip11|TFIP11]]|0.472|
|[[:human genes:s:syt9|SYT9]]|0.47|
|[[:human genes:n:ndc80|NDC80]]|0.467|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.465|
|[[:human genes:m:mt1e|MT1E]]|0.464|
|[[:human genes:h:hap1|HAP1]]|0.464|
|[[:human genes:g:golga6a|GOLGA6A]]|0.462|
|[[:human genes:s:sec13|SEC13]]|0.46|
|[[:human genes:n:nup160|NUP160]]|0.459|
|[[:human genes:p:psma6|PSMA6]]|0.458|
|[[:human genes:t:twistnb|TWISTNB]]|0.458|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.452|
|[[:human genes:c:cox8a|COX8A]]|0.452|
|[[:human genes:p:psmd1|PSMD1]]|0.445|
|[[:human genes:r:rps12|RPS12]]|0.445|
|[[:human genes:c:c14orf93|C14orf93]]|0.442|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.441|
|[[:human genes:f:fam25b|FAM25B]]|0.44|
|[[:human genes:z:znf830|ZNF830]]|0.439|
|[[:human genes:c:cdc73|CDC73]]|0.438|
|[[:human genes:c:chd4|CHD4]]|0.437|
|[[:human genes:p:psmd3|PSMD3]]|0.437|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.436|
|[[:human genes:o:ogfr|OGFR]]|0.436|
|[[:human genes:d:dock6|DOCK6]]|0.433|
|[[:human genes:r:rbm39|RBM39]]|0.431|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.43|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.43|
|[[:human genes:r:rps14|RPS14]]|0.429|
|[[:human genes:p:psmc5|PSMC5]]|0.426|
|[[:human genes:f:fam160a1|FAM160A1]]|0.426|
|[[:human genes:d:disp2|DISP2]]|0.426|
|[[:human genes:k:kctd17|KCTD17]]|0.425|
|[[:human genes:d:ddtl|DDTL]]|0.425|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.424|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.424|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.424|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.423|
|[[:human genes:c:ccdc94|CCDC94]]|0.421|
|[[:human genes:g:golga6b|GOLGA6B]]|0.421|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.42|
|[[:human genes:p:prpf8|PRPF8]]|0.42|
|[[:human genes:c:cdc45|CDC45]]|0.42|
|[[:human genes:c:cbwd5|CBWD5]]|0.42|
|[[:human genes:p:plk4|PLK4]]|0.42|
|[[:human genes:w:wdr87|WDR87]]|0.419|
|[[:human genes:p:psmb4|PSMB4]]|0.418|
|[[:human genes:c:copg1|COPG1]]|0.417|
|[[:human genes:p:psmd11|PSMD11]]|0.417|
|[[:human genes:t:ticrr|TICRR]]|0.416|
|[[:human genes:t:trappc2l|TRAPPC2L]]|0.41|
|[[:human genes:a:apc2|APC2]]|0.408|
|[[:human genes:e:exosc5|EXOSC5]]|0.407|
|[[:human genes:n:npipb5|NPIPB5]]|0.407|
|[[:human genes:c:cbwd6|CBWD6]]|0.406|
|[[:human genes:e:exd1|EXD1]]|0.406|
|[[:human genes:c:cdc6|CDC6]]|0.406|
|[[:human genes:x:xylt2|XYLT2]]|0.405|
|[[:human genes:e:elmod3|ELMOD3]]|0.405|
|[[:human genes:r:rpl37a|RPL37A]]|0.403|
|[[:human genes:c:cbwd3|CBWD3]]|0.403|
|[[:human genes:m:myo1h|MYO1H]]|0.403|
|[[:human genes:u:utp20|UTP20]]|0.403|
|[[:human genes:c:cnpy3|CNPY3]]|0.402|
|[[:human genes:r:rps5|RPS5]]|0.402|
|[[:human genes:p:pold1|POLD1]]|0.401|
|[[:human genes:o:orc1|ORC1]]|0.401|
|[[:human genes:t:ttyh1|TTYH1]]|0.4|
|[[:human genes:n:nsf|NSF]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1923
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CMYA5 Expression in NALM6 Cells: 1.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>