CNEP1R1 [The Human Chemical-Genetic Interaction Map Project]

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======= CNEP1R1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNEP1R1
  * **<color #00a2e8>Official Name</color>**: CTD nuclear envelope phosphatase 1 regulatory subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=255919|255919]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N9A8|Q8N9A8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNEP1R1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNEP1R1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616869|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. {ECO:0000269|PubMed:22134922}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tmemb 18A|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Nem1-Spo7 phosphatase complex|
|mitotic nuclear envelope disassembly|
|positive regulation of triglyceride biosynthetic process|
|membrane disassembly|
|nuclear envelope disassembly|
|regulation of triglyceride biosynthetic process|
|positive regulation of triglyceride metabolic process|
|regulation of triglyceride metabolic process|
|positive regulation of protein dephosphorylation|
|nuclear envelope organization|
|positive regulation of dephosphorylation|
|positive regulation of lipid biosynthetic process|
|nucleus organization|
|regulation of protein dephosphorylation|
|positive regulation of lipid metabolic process|
|protein localization to nucleus|
|nuclear envelope|
|regulation of lipid biosynthetic process|
|regulation of dephosphorylation|
|nuclear membrane|
|regulation of lipid metabolic process|
|cellular component disassembly|
|endomembrane system organization|
|mitotic cell cycle process|
|mitotic cell cycle|
|protein localization to organelle|
|membrane organization|
|cell cycle process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|lipid metabolic process|
|positive regulation of protein modification process|
|cell cycle|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.6|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.23|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.2|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.16|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.02|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.99|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.97|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.88|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.72|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.8|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.85|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.626|
|[[:human genes:c:cept1|CEPT1]]|0.431|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.428|
|[[:human genes:f:flvcr1|FLVCR1]]|0.424|
|[[:human genes:c:chka|CHKA]]|0.421|
|[[:human genes:k:kdsr|KDSR]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19008
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNEP1R1 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>